You would have to call the prometric test center and ask. It may be possible.
Honestly, I have only taken the USMLE exams on weekdays. They may not offer the exam on the weekend.
Usually on the scheduling calendar, they will indicate the available days for the exam at the specific prometric test center. If you see a weekend date, then you have your answer.
I did both Step1 and Step 2CS (Houston) on saturdays and will schedule my CK for saturday too. Just check out the schedules on the different Prometric centers within your reach.
I'm signed up to take my Step 2 CK on a Saturday this July at a Sulvan sp? learning/prometric center. Hours/days open depend on the individual center's business hours. Some are even open on state holidays.
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