Stress Testing!!

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adagio

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Hello everyone,

1- Are the contraindications to EXERCISE stress testing (such as MI, Aortic Dissection, HOCM, severe AS etc) are they the same for all kinds of Stress testing (nuclear, echocardiographical etc)? I suspect they are.

2- what is a significant ST change on stress test? is it 1 mm or 2 mm? (I have read somewhere its 1 mm, but in kaplan they say its 2 mm), and what is its shape? (is it downslope, upslope, depression?
 
1- Are the contraindications to EXERCISE stress testing (such as MI, Aortic Dissection, HOCM, severe AS etc) are they the same for all kinds of Stress testing (nuclear, echocardiographical etc)? I suspect they are.

Actually, nuclear and echo are not stress testing, but imaging methods. All those technetium atoms aren't stressing the heart out 🙂 There are two main ways to produce stress on heart: Either by exercising (exercise stress test) or by pharmacological agents (dipyrimadole stress test or dobutamine stress test). Contraindications for these tests are similar, so I would like to add two points: (1) Dipyrimadole stress test is contraindicated with severe reactive airways - so if the patient is actively wheezing, don't perform it (2) If both of them create stress on heart, why just not do exercise and don't waste any money on drugs? Some patients may have musculoskeletal problems that would prevent them from exercise. For example, what would you do if the patient has a broken leg? Would you rather wait for weeks for the leg to heal? So, pharmacological agents are suitable for patients who can't perform exercise testing for musculoskeletal reasons.

So what is the "stress test"? It generally means electrocardiographic treadmill exercise test. It's done according to specific protocols (usually Bruce protocol).

Cardiac imaging (whether it's echocardiography, nuclear methods or CT/MRI) can be done both on the resting heart or during cardiac stress (either exercise or pharmacological).

2- what is a significant ST change on stress test? is it 1 mm or 2 mm? (I have read somewhere its 1 mm, but in kaplan they say its 2 mm), and what is its shape? (is it downslope, upslope, depression?

Both are correct actually 🙂

By definition, if 0,1 mV = 1 mm on EKG (it should always be checked), 1 mm horizontal or down-slopping ST depression is considered to be positive. But when 1 mm depression is accepted as positive, there will be many false positive cases. This is especially important for a younger patient, where the pre-test probability of a coronary artery disease is already lower. When 2 mm is accepted to be positive ("severe" ST depression), false positives become uncommon. So, if there's a >2 mm ST elevation, it's interpreted as "indicative of severe CAD".
 
Hi Fuzuli, I want to ask you, which is better: Nuclear uptake or Echocardiography? and are there any instances that we use one instead of the other when EKG interpretation is not feasible?

also, do you recommend any site that has EKGs that might be enough for step 2 exam to study?
 
Hi Fuzuli, I want to ask you, which is better: Nuclear uptake or Echocardiography? and are there any instances that we use one instead of the other when EKG interpretation is not feasible?

also, do you recommend any site that has EKGs that might be enough for step 2 exam to study?

The test to choose depends on your objective: What do you want to know?

- Echocardiography provides additional information on heart structure. So if there's a concomittant aortic disease, valve disease or pericardial disease, echo is better.

- If you want to compare a previously infarcted area, nuclear imaging is preferred.

For the EKG's: Sorry, I don't know any good websites. 🙁
 
But in kaplan they use both modalities for the sake of investigating a possible ischemic event during stressing, and hence my question: if a patient comes with history of Angina, he has a previous EKG with LBBB abnormality from long time ago that is present on the current EKG, clearly this person cannot undergo EKG stress testing, but rather would require either a nuclear or echocardiographic testing: which one would you choose?
 
But in kaplan they use both modalities for the sake of investigating a possible ischemic event during stressing, and hence my question: if a patient comes with history of Angina, he has a previous EKG with LBBB abnormality from long time ago that is present on the current EKG, clearly this person cannot undergo EKG stress testing, but rather would require either a nuclear or echocardiographic testing: which one would you choose?

Let me put it this way:

A 45 year old man is referred to the cardiology outpatient clinic for evaluation of substernal chest pain not responding to PPIs. He has had this pain for 3 years. He says his pain is relieved somewhat with ibuprofen. He has a 20 pack-years history of smoking and medically controlled hypertension. His physical examination and EKG is normal. What is the best next step?

a) Standard exercise EKG test
b) Stress echocardiography
c) Stress myocardial perfusion nuclear imaging
d) Coronary angiography
e) Energy beam CT coronary angiography


There are three questions that need to be answered in this patient:

(1) Does he need a stress test?
(2) Can he physically handle exercise?
(3) Are there contraindications for the standard exercise stress test?

For (1), we have to talk about the pretest probability of the patient. Basically, patients are grouped into low (pretest probability <%10), intermediate (%10-90) and high risk (>%90) categories based on their age, gender and symptoms (1-Substernal pain 2-Increased with exercise 3-Relieved by rest). He has a relatively young age and has only one of the three classical symptoms, which puts him in the intermediate category. Since he belongs to intermediate category, he needs a stress test. If he were 30 years of age, his pretest probability would be lower than <%10, which would put him into low risk category. In that case, he wouldn't need a stress that.

So, he satisfies (1)

For (2), there's nothing in the question stem that would prevent him from exercising. But if he had severe exercise-induced asthma, that would have prevented him from exercising.

For (3), he doesn't have the contraindications for the stress that, such as LBBB, digoxin therapy, ventricular paced rhythm, previous CABG, etc. You've already written about these contraindications in your first post.

Therefore, a standard exercise EKG stress test is the most appropriate choice.

A 45 year old man is referred to the cardiology outpatient clinic for evaluation of substernal chest pain not responding to PPIs. He has had this pain for 3 years. He says his pain is relieved somewhat with ibuprofen. He has a 20 pack-years history of smoking, medically controlled hypertension and severe exercise-induced asthma. His physical examination reveals a 2/6 harsh systolic ejection murmur at second right intercostal space, which radiates to his neck. His EKG shows LVH and 1 mV ST segment depressions at leads V2 and V3. What is the best next step?

a) Standard exercise EKG test
b) Stress echocardiography
c) Stress myocardial perfusion nuclear imaging
d) Coronary angiography
e) Energy beam CT coronary angiography


Since exercise induced asthma would prevent him from exercising, a pharmacologic stress imaging study is required (choices B and C). Since he has a cardiac murmur consistent with aortic stenosis and that would also be needed to be controlled, echocardiogaphy is superior to nuclear imaging for this patient. Therefore, the answer is B.

A 45 year old man is referred to the cardiology outpatient clinic for evaluation of substernal chest pain not responding to PPIs. He has had this pain for 3 years. He says his pain is relieved somewhat with ibuprofen. He has a 20 pack-years history of smoking and medically controlled hypertension. He has a note from his primary physician that his medical records are incomplete and he may had an acute coronary event one year ago. His physical examination reveals no apparent murmurs. His EKG shows LBBB. What is the best next step?

a) Standard exercise EKG test
b) Stress echocardiography
c) Stress myocardial perfusion nuclear imaging
d) Coronary angiography
e) Energy beam CT coronary angiography


Now this is somewhat contrived by I didn't want to change the whole question stem 🙂 Since he has LBBB, he's not eligible for the standard stress test. In addition, he may have had a previous coronary event, so determination of the location and extent of ischemia is needed and nuclear imaging is superior for this purpose. Therefore, the answer is C.

Hope this helps.
 
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Let me put it this way:

A 45 year old man is referred to the cardiology outpatient clinic for evaluation of substernal chest pain not responding to PPIs. He has had this pain for 3 years. He says his pain is relieved somewhat with ibuprofen. He has a 20 pack-years history of smoking and medically controlled hypertension. His physical examination reveals a 2/6 harsh systolic ejection murmur at second right intercostal space, which radiates to his neck. His EKG shows LVH and 1 mV ST segment depressions at leads V2 and V3. What is the best next step?

a) Standard exercise EKG test
b) Stress echocardiography
c) Stress myocardial perfusion nuclear imaging
d) Coronary angiography
e) Energy beam CT coronary angiography

There are three questions that need to be answered in this patient:

(1) Does he need a stress test?
(2) Can he physically handle exercise?
(3) Are there contraindications for the standard exercise stress test?

For (1), we have to talk about the pretest probability of the patient. Basically, patients are grouped into low (pretest probability <%10), intermediate (%10-90) and high risk (>%90) categories based on their age, gender and symptoms (1-Substernal pain 2-Increased with exercise 3-Relieved by rest). He has a relatively young age and has only one of the three classical symptoms, which puts him in the intermediate category. Since he belongs to intermediate category, he needs a stress test. If he were 30 years of age, his pretest probability would be lower than <%10, which would put him into low risk category. In that case, he wouldn't need a stress that.

So, he satisfies (1)

For (2), there's nothing in the question stem that would prevent him from exercising. But if he had severe exercise-induced asthma, that would have prevented him from exercising.

For (3), he doesn't have the contraindications for the stress that, such as LBBB, digoxin therapy, ventricular paced rhythm, previous CABG, etc. You've already written about these contraindications in your first post.

Therefore, a standard exercise EKG stress test is the most appropriate choice.

He has LVH (and st depression) on resting EKG, LVH alone on EKG will hinder the interpretation of EKG on stress (according to Dr. Fischer), so I think EKG stress test is not appropriate, and we should do either nuclear or echo stress, and since he has a murmur, i would say Echo is most suitable with the stress. what do you think?

As far as your two other scenarios, they are very convincing
 
He has LVH (and st depression) on resting EKG, LVH alone on EKG will hinder the interpretation of EKG on stress (according to Dr. Fischer), so I think EKG stress test is not appropriate, and we should do either nuclear or echo stress, and since he has a murmur, i would say Echo is most suitable with the stress. what do you think?

As far as your two other scenarios, they are very convincing

Oops, copy-paste error 🙂 The first question stem is not eligible for a standard EKG stress test because he has AS in the first place. I must've pasted the second half of the second question into the first by accident. Here's the correct stem:

A 45 year old man is referred to the cardiology outpatient clinic for evaluation of substernal chest pain not responding to PPIs. He has had this pain for 3 years. He says his pain is relieved somewhat with ibuprofen. He has a 20 pack-years history of smoking and medically controlled hypertension. His physical examination and EKG is normal. What is the best next step?

a) Standard exercise EKG test
b) Stress echocardiography
c) Stress myocardial perfusion nuclear imaging
d) Coronary angiography
e) Energy beam CT coronary angiography
 
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hahaha even the mystic fuzuli makes an error 😛 loool

Thanks a lot ... when you have time, could you take a look at my other inquiries?! 😀
 
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