succinylcholine

[jughead00]

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Does anyone know why succinycholine causes hypercalcemia and hyperkalemia???

 

[Phloston]

nAChR is a non-selective cation channel that releases lots of K+ (and Ca2+) when succinylcholine is administered.

Remember that nAChR are ionotropic (channels that open in response to ligand-binding) and mAChR are metabotropic (act via 2nd messengers).

I've seen in practice questions that nAChR are LIGAND-gated Na+/K+ channels (NOT Na/K-ATP-pumps), such that Na+ influxes AND K+ EFFLUXES when nAChR is activated.

Done deal.

 

[jughead00]

nAChR is a non-selective cation channel that releases lots of K+ (and Ca2+) when succinylcholine is administered.

Remember that nAChR are ionotropic (channels that open in response to ligand-binding) and mAChR are metabotropic (act via 2nd messengers).

I've seen in practice questions that nAChR are LIGAND-gated Na+/K+ channels (NOT Na/K-ATP-pumps), such that Na+ influxes AND K+ EFFLUXES when nAChR is activated.

Done deal.

Wonderful!!! I got it. Thanks a lot 👍