Sumatriptan MOA

[Cliff Huxtable]

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In the Pharm section of FA2009, it says triptans are 5-HT1A agonists. In the Neuro section, it says Sumatriptan is a 5-HT1B/1D agonist.

Is it both?

 

[GujuMD]

In the Pharm section of FA2009, it says triptans are 5-HT1A agonists. In the Neuro section, it says Sumatriptan is a 5-HT1B/1D agonist.

Is it both?

The mechanism for treating migraine for triptans as far as i know is via 5-HT-1D.

 

[sendwich]

I've only seen 1B/1D (and this was from way back in one of my neuro classes)

 

[Cliff Huxtable]

I've only seen 1B/1D (and this was from way back in one of my neuro classes)

Wikipedia agrees with you