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NSAIDs constipation MOA

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Maddox_doc

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Dear friends,

I understand how opiods, anticholinergics, Fe, CCB, and diuretics can cause constipation. But can someone explain how NSAIDs cause constipation? What is the mechanism of action? o_O
 

Phloston

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Dear friends,

I understand how opiods, anticholinergics, Fe, CCB, and diuretics can cause constipation. But can someone explain how NSAIDs cause constipation? What is the mechanism of action? o_O

Probably a direct effect of the decreased prostaglandin synthesis. Found this article:

https://www.ncbi.nlm.nih.gov/pubmed/3883808

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Also found this article: http://onlinelibrary.wiley.com/stor...7p&s=3a86ce382afec52260e4b38e4cb3290a087df0e5

"Similarly, we found that NSAIDs were a risk factor for constipation. However, we also found a significant association between acetaminophen and aspirin use in chronic constipation. As prostaglandin analogues often cause diarrhoea, it can be theorized that inhibitors of prostaglandin synthesis by drugs, such as aspirin or other NSAIDs could potentially aggravate or induce constipation...The possible anti-serotonergic effects of acetaminophen might account for this association with constipation. The role of serotonin signalling in the GI tract is known to be critical, being involved in the regulation of motility, secretion and sensation."
 
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