T-cell independent vaccines

[dbeast]

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I just read that the pneumococcus vaccine elicits a T-cell independent response and does not create IgG antibodies. Somehow this is related to the fact that it's based on its polysaccharide capsule.

So my question is... what in the world does this mean? What type of sustained response does the vaccine generate if it's not IgG? Thanks people!

 

[bangarang]

I just read that the pneumococcus vaccine elicits a T-cell independent response and does not create IgG antibodies. Somehow this is related to the fact that it's based on its polysaccharide capsule.

So my question is... what in the world does this mean? What type of sustained response does the vaccine generate if it's not IgG? Thanks people!

Remember that peptides are presented to T-cells to promote class switching, so without a conjugated peptide to the polysaccharide capsule, there will be no T-cell activation and subsequent class switching to IgG. Only IgM antibodies will be produced.

 

[RIPSanto]

I just read that the pneumococcus vaccine elicits a T-cell independent response and does not create IgG antibodies. Somehow this is related to the fact that it's based on its polysaccharide capsule.

So my question is... what in the world does this mean? What type of sustained response does the vaccine generate if it's not IgG? Thanks people!

Pneumovax = capsular antigens only (polysaccharide). as stated above, T-cell activation is required for class switching and affinity maturation, so only IgM is made

Prevnar = capsular ag conjugated to some protein. this allows TCell activation and IgG abs

 

[dbeast]

Awesome, thanks! I guess I somehow overlooked the fact that IgM can provide longstanding immunity as well.

 

[RIPSanto]

Awesome, thanks! I guess I somehow overlooked the fact that IgM can provide longstanding immunity as well.

Not exactly sure about this either? Maybe someone else can clarify. I certainly wouldn't associate IgM with long term protection. Also, the T-cell independent vaccinces usually require booster shots. Maybe this is where the long term protection lies?

 

[Jamiu22]

I just read that the pneumococcus vaccine elicits a T-cell independent response and does not create IgG antibodies. Somehow this is related to the fact that it's based on its polysaccharide capsule.

So my question is... what in the world does this mean? What type of sustained response does the vaccine generate if it's not IgG? Thanks people! ?

I saw the questions below in RX, thought they were interesting... just thought to share:

A 24yr old from Venezuela comes to your local free clinic at 16wks gestation? She has a history of seizures... so you decide to administer a vaccine to her; which vaccine is okay for you to administer:

a. MMR
b. DPT
c. Killed polio
d. Varicella
e. Yellow Fever



2. Which of the following infectious organisms is best controlled by the cell-mediated arm of the immune system, as opposed to the humoral arm of the immune system?

a. clostridium perfinges
b. listeria monocytogenes
c. Staph areus
d. Strep Viridans
e. Strep Pyogenes.

 

[223556]

I saw the questions below in RX, thought they were interesting... just thought to share:

A 24yr old from Venezuela comes to your local free clinic at 16wks gestation? She has a history of seizures... so you decide to administer a vaccine to her; which vaccine is okay for you to administer:

a. MMR
b. DPT
c. Killed polio
d. Varicella
e. Yellow Fever



2. Which of the following infectious organisms is best controlled by the cell-mediated arm of the immune system, as opposed to the humoral arm of the immune system?

a. clostridium perfinges
b. listeria monocytogenes
c. Staph areus
d. Strep Viridans
e. Strep Pyogenes.

1) c? are live vaccines just unsafe for the baby? (for whatever reason that I'm hoping someone can explain...I have written down that you can't give DTaP to seizure pts.
2) b - its an intracellular organism

 

[Jamiu22]

1) c? are live vaccines just unsafe for the baby? (for whatever reason that I'm hoping someone can explain...I have written down that you can't give DTaP to seizure pts.
2) b - its an intracellular organism

Sweet! you got both correct... I missed both when I did it...

For the first one... you don't give live attenuated vaccines to pregnant women because they are in a way - immunocompromised. Also, the baby could be susceptible to the infection since their immune system isn't well developed (even though they get Igg from mommy's placenta).

 

[bangarang]

Sweet! you got both correct... I missed both when I did it...

For the first one... you don't give live attenuated vaccines to pregnant women because they are in a way - immunocompromised. Also, the baby could be susceptible to the infection since their immune system isn't well developed (even though they get Igg from mommy's placenta).

I got the Listeria one correct, but the seizures line from the first one threw me off. Was confused why some vaccines would be contraindicated in a patient with seizures.