Take with food

[FruitFly]

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What does it mean?

How much food? What type of food? Steak dinner? Omlet? Glass of Milk?/crackers
I would imagine that there are specific caloric/fat/protein criteria for pharmaceutical studies to support - 'taking with food'.

 

[crazybob]

What does it mean?

How much food? What type of food? Steak dinner? Omlet? Glass of Milk?/crackers
I would imagine that there are specific caloric/fat/protein criteria for pharmaceutical studies to support - 'taking with food'.

I usually take with a regular meal. A combo meal at a fast-food restaurant would probably be more than enough

What was your guess on how much food it would require?

 

[Praziquantel86]

What does it mean?

How much food? What type of food? Steak dinner? Omlet? Glass of Milk?/crackers
I would imagine that there are specific caloric/fat/protein criteria for pharmaceutical studies to support - 'taking with food'.

The FDA actually has a standardized meal that companies will use in clinical trials. I can't remember the specifics, but I remember it being a pretty darn hearty breakfast (few eggs, bacon, glass of milk, the whole bit). I'm sure you can find it online somewhere.

 

[npage148]

D. Test Meal
We recommend that food-effect BA and fed BE studies be conducted using meal conditions that are expected to provide the greatest effects on GI physiology so that systemic drug availability is maximally affected. A high-fat (approximately 50 percent of total caloric content of the meal) and high-calorie (approximately 800 to 1000 calories) meal is recommended as a test meal for food-effect BA and fed BE studies. This test meal should derive approximately 150, 250, and 500-600 calories from protein, carbohydrate, and fat, respectively.(4) The caloric breakdown of the test meal should be provided in the study report. If the caloric breakdown of the meal is significantly different from the one described above, the sponsor should provide a scientific rationale for this difference. In NDAs, it is recognized that a sponsor can choose to conduct food-effect BA studies using meals with different combinations of fats, carbohydrates, and proteins for exploratory or label purposes. However, one of the meals for the food-effect BA
studies should be the high-fat, high-calorie test meal described above.

(4) An example test meal would be two eggs fried in butter, two strips of bacon, two slices of toast with butter, four ounces of hash brown potatoes and eight ounces of whole milk. Substitutions in this test meal can be made as long as the meal provides a similar amount of calories from protein, carbohydrate, and fat and has comparable meal volume and viscosity.

Food-Effect Bioavailability and Fed Bioequivalence Studies

 

[Praziquantel86]

Food-Effect Bioavailability and Fed Bioequivalence Studies

That breakfast is awesome. I feel like you would need to enroll in some sort of statin study just to justify eating it every day.

 

[TWO515TY]

I think the more important thing about the "take with food" instruction is to put it separately from the rest of the instructions, so that the patient knows that they have to eat when they take the medicine, not take the medicine every time they eat (depending on the medication and instructions of course).

For example, we had a parent say she ran out of her daughter's prednisolone suspension on the second day, but it was supposed to last for 5 days.

I looked at the script and it was typed as:

Prednisolone 15/5: Take 1 teaspoonful by mouth every day after meals for 5 days

^That's the sig that was typed on the Rx bottle. She was giving her daughter the Prednisolone 3 times a day (breakfast, lunch, dinner).

The hardcopy said: Prednisolone 15/5, 1 ts po qd pc x 5 days, dispense 25 mL

If you read it literally, then the sig on the bottle is correct. However, the proper direction should have been:

Give 1 teaspoonful by mouth once daily for 5 days (give with food)

Give, not take because it's a child, and once daily because the script says qd not tid. Whenever I type scripts that say pc or ac, I always write the "with food" part at the end, and specify exactly how many times a day (once, twice, three times, etc) the med is supposed to be given.

As far as what to eat, unless specified somewhere, most regular meals are ok. Depending on the medicine, eating food can be more to prevent stomach upset than to increase the efficacy of the medication.

 

[type b pharmD]

I think the more important thing about the "take with food" instruction is to put it separately from the rest of the instructions, so that the patient knows that they have to eat when they take the medicine, not take the medicine every time they eat (depending on the medication and instructions of course).

For example, we had a parent say she ran out of her daughter's prednisolone suspension on the second day, but it was supposed to last for 5 days.

I looked at the script and it was typed as:

Prednisolone 15/5: Take 1 teaspoonful by mouth every day after meals for 5 days

^That's the sig that was typed on the Rx bottle. She was giving her daughter the Prednisolone 3 times a day (breakfast, lunch, dinner).

The hardcopy said: Prednisolone 15/5, 1 ts po qd pc x 5 days, dispense 25 mL

If you read it literally, then the sig on the bottle is correct. However, the proper direction should have been:

Give 1 teaspoonful by mouth once daily for 5 days (give with food)

Give, not take because it's a child, and once daily because the script says qd not tid. Whenever I type scripts that say pc or ac, I always write the "with food" part at the end, and specify exactly how many times a day (once, twice, three times, etc) the med is supposed to be given.

As far as what to eat, unless specified somewhere, most regular meals are ok. Depending on the medicine, eating food can be more to prevent stomach upset than to increase the efficacy of the medication.

Smart thinking!!! i know ive been to pharmacies where they've made that mistake before