Let's see. I took a total of four years between graduating and medical school, although I wasn't 100% committed to MS before doing that (I was still indulging in my roaring twenties). I had a career, traveled in the Middle East and worked there as a volunteer, bartended while studying for my MCATS . . . and generally had a good time. Should what you do in a year off be directly relevant to MS? Maybe. A lot of people will argue yes. My girlfriend, who was on last year's ADCOM, interviewed a lot of fresh-faced newly grads and a handful of people who did interesting non-medical things with their life. Generally, she was more impressed with the people who traveled, led community lives, started families . . . in other words, established their "real-life" credibility with experience. That's not to say new grads don't have what it takes to be great doctors--of course they do! Only you know the limits and peculiarities of your own emotional health, though. The nontrads I know don't complain that they're missing out on being "young," while some of my new-grad friends often bitterly complain that their friends are having a good time while they're slaving away.