telomerase and topoisomerase
Started by atlanta213
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As far as I remember from biochm, telomerase is a protein that adds a specific nucleotide repeats to the end of the chromosome. And I think they replace the certain areas in the DNA which is called telomere which protect the chromosomes.
Telomerase is grossly overexpressed in over 90% of human cancers. It allows cancer cells to overcome the hayflick limit, the built in limit on the number of times a cell can divide to form a new one. Even though in cancer telomerase is turned on, telomeres are still short due to the high growth rate of cancer cells, and especially cancer stem cells.
When telomerase is activated in cancer, over 70 genes are switched to grwoth/cancer mode (Elizabeth Blackburn, Lasker Prize for telomerase research and discovery)
Telomerase add TTAGGG repeats to the prime 3 end of the double helix, ans so adds sacrificial lenth, other wise in the violence of cell division, when chromosomes rip apart, real DNA would be lost and the cell would die. This death is the hayflick limit.
Blackburn also did work on stress of caregivers and matched their reported emotional stress levels to the length of their telomeres (shorter with more emotional stress). Short telomeres in normal cells can result in telomeric crisis, which can result in senescence, cancer, or apoptosis.
More recent research (last couple weeks) shows that when stress activates cortisol, the cortisol interferes with telomerase in normal T cells. So the T cells die early and probably don't get produced as quickly as required. Stress then should be considered both a carcinogen, and a predictor of morality from diverse diseases.
I hope this is helpful.
Here are some telomerase studies on my messy website, nothing is for sale there, its just a site of studies and notes:
www.geocities.com/prime3end
It's ironic , but telomerase keeps us young, and too little of it in a healthy person makes us unhealthy, and emotional stress is the best way to make yourself sick. But in a cancer cell it is the heart and soul of cancer. Robt A Weinberg switches only 3 or 4 genes and causes cancer in "many human cell types", he always has to switch on the gene for telomerase. He won the Otto Warburg indsutry prize for his groundbreaking work. A company, TA Bioscience is now selling a product that activates telomerase for the sake of good health. Its an extract of astragalus.
There is a database on telomerase, if you need it, email me at prime3end atttttttt
yahoo junktofoolspamengines com and I'll dig up the link for you.
When telomerase is activated in cancer, over 70 genes are switched to grwoth/cancer mode (Elizabeth Blackburn, Lasker Prize for telomerase research and discovery)
Telomerase add TTAGGG repeats to the prime 3 end of the double helix, ans so adds sacrificial lenth, other wise in the violence of cell division, when chromosomes rip apart, real DNA would be lost and the cell would die. This death is the hayflick limit.
Blackburn also did work on stress of caregivers and matched their reported emotional stress levels to the length of their telomeres (shorter with more emotional stress). Short telomeres in normal cells can result in telomeric crisis, which can result in senescence, cancer, or apoptosis.
More recent research (last couple weeks) shows that when stress activates cortisol, the cortisol interferes with telomerase in normal T cells. So the T cells die early and probably don't get produced as quickly as required. Stress then should be considered both a carcinogen, and a predictor of morality from diverse diseases.
I hope this is helpful.
Here are some telomerase studies on my messy website, nothing is for sale there, its just a site of studies and notes:
www.geocities.com/prime3end
It's ironic , but telomerase keeps us young, and too little of it in a healthy person makes us unhealthy, and emotional stress is the best way to make yourself sick. But in a cancer cell it is the heart and soul of cancer. Robt A Weinberg switches only 3 or 4 genes and causes cancer in "many human cell types", he always has to switch on the gene for telomerase. He won the Otto Warburg indsutry prize for his groundbreaking work. A company, TA Bioscience is now selling a product that activates telomerase for the sake of good health. Its an extract of astragalus.
There is a database on telomerase, if you need it, email me at prime3end atttttttt
yahoo junktofoolspamengines com and I'll dig up the link for you.
