The Difference Between Extrinic and Intrinsic Pathway?

[Solace]

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This is one of those thinsg I never really got clarification on. What is the diiference between the extrinsinc and intrinsic pathways of coagulation? Thanks.

 

[Olanzapine]

http://www.med.unibs.it/~marchesi/blood.html#image

 

[Solace]

Thanks for the link. I guess a better question would be why do they call it the intrinsic and extrinsic pathway, respectively.

 

[Olanzapine]

Intrinsic is called intrinsic because all of it's factors are found in the blood. Extrinisic is called extrinsic because it uses Tissue Factor (TF), which is not found in the blood but is released when tissues are injured. On a side note, TF isn't required for the extrinsic pathway (factor VII can be used to activate the extrinsic pathway at a *much* slower rate)

 

[Solace]

Thank you for that great explanation. Now I can die in peace.