Conclusion
Brain activity related to the perception of back pain shifts in location from regions involved in acute pain to engage emotion circuitry as the condition persists, thereby providing a percept-linked brain signature for the transition to chronic pain. We provide a spatial template and time window (6–12 months) for the stabilization of this signature, which identifies a specific functional bio-marker for back pain chronification. Thus, these results have important clinical implications regarding the definition of chronic pain, its aetiology, and the optimal time window for treatments targeting its prevention. Additionally, these results challenge long standing theoretical constructs of brain-mind relationships