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Figured I'd start this one out. I'll be registering for the MCAT first thing tomorrow. Who else is taking it on this date? How do you all plan on studying over the school year?
Just finished EK Bio lecture 4..
I didn't get the nervous system before, and I certainly don't get it now.
Neurophysiology is my ish Rose, whatchu need?
Thanks! I never took neuroanatomy/neurophysiology, so I'm a bit hazy on what the difference is between pre-ganglion and post-ganglionic neurons of either the sympathetic or the parasympathetic autonomic nervous systems.
You guys rock!!! And i just finished metabolic pathways NOT USING TBR lol
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Okay I got you! I will write you out a response soon, I promise. I'm a bit backed up right at the moment hah.
Damn. The date that I registered for is may 30th 🙁! Because the only other available time in April is literally on the days I have finals. Sigh! I'm going to create the May 30 thread. I guess I will be using up all the TBR/ TPRH science workbook passages...
snip .
Soooo is anybody else bombing these BR bio passages??? Idk if its just a weak background in biochem (haven't taken it yet) or if its just me not reading the detailed BR passages. I read TPR cellular respiration passages and supplemented it with TBR a little and I felt really good about it. I know the MCAT is a test of scientific intuition to an extent...so idk what's going on...
Good luck to you! Don't stop posting here all together, after all, we're all in this together.
Yea, I find the BR Bio to be difficult as well, especially the second book. I am also using TPR bio book for content review and doing BR + TPR workbook for passages. Don't you find the TPR passages to be much easier than BR?
Soooo is anybody else bombing these BR bio passages??? Idk if its just a weak background in biochem (haven't taken it yet) or if its just me not reading the detailed BR passages. I read TPR cellular respiration passages and supplemented it with TBR a little and I felt really good about it. I know the MCAT is a test of scientific intuition to an extent...so idk what's going on...
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Ah! I'm didn't foresee this happening at all but when I tried to register for May 23 this past Friday I realized there were NO seats in my area, not even the surrounding area. 🙁
I feel kind of silly that I missed the date. But I didn't realize that seats would be gone in my area so quickly because last year I noticed that there were open slots month before test dates for august (my original day before I postponed).
Damn. The date that I registered for is may 30th 🙁! Because the only other available time in April is literally on the days I have finals. Sigh! I'm going to create the May 30 thread. I guess I will be using up all the TBR/ TPRH science workbook passages...
Thanks! I never took neuroanatomy/neurophysiology, so I'm a bit hazy on what the difference is between pre-ganglion and post-ganglionic neurons of either the sympathetic or the parasympathetic autonomic nervous systems.
Thanks! I never took neuroanatomy/neurophysiology, so I'm a bit hazy on what the difference is between pre-ganglion and post-ganglionic neurons of either the sympathetic or the parasympathetic autonomic nervous systems.
I don't know what level of detail you are looking for, but a simplistic answer is that pre-ganglionic neurons originate in the spinal cord and then synapse with a post-ganglionic neuron. This post-ganglionic neuron then goes on to act on the organ.
nice!
i am submitting a polite request for more Ochem facts of the day GTLO 😎
Exactly!
Ganglia, masses of neural cell bodies in the peripheral nervous system, serve as junctions between fibers originating in the CNS and those that synapse with the effectors (either glands or muscles). Preganglionic and postganglionic refer to the location of neurons relative to the synapse at a given ganglion. Since all autonomic nervous signals originate in the CNS, the preganglionic neurons of both the sympathic and parasympathic divisions have their cell bodies located in either the brain or spinal cord. These cell bodies extend axons out to their respective ganglia and synapse with the postganglionic neurons. Since the synapsis actually occurs in the ganglion itself, the postganglionic neurons have their cell bodies within the ganglia, and their axons conduct the signal beyond. These postganglionic neurons are true PNS cells.
Now, what are the differences between the sympathetic and parasympathetic pathways? The two major differences are in location and neurotransmitters used.
Let's address location first: Between the symp. and parasymp. divisions there are differences in the locations within the brain and spinal cord from which the preganglionic signal originates, but let's ignore those for the sake of focus on ganglionic transmission.
Put simply, the sympathetic ganglia are settled close to the CNS and far from the effectors, closest to the spinal cord in the paravertebral region.
In contrast, the parasympathetic ganglia are near to or even inside their effectors.
On to neurotransmitters, as a guideline, the parasympathetic division uses acetylcholine exclusively. Both preganglionic and postganglionic parasympathetic neurons are cholinergic.
As another guideline, all preganglionic neurons use acetylcholine. This means that preganglionic sympathetic neurons use acetylcholine just as the parasympathetic do. However, in the sympathetic nervous system, postganglionic neurons use epinephrine or norepinephrine (adrenaline or noradrenaline) as neurotransmitters instead of acetylcholine. Postganglionic parasympathetic neurons and the receptors they release neurotransmitters onto are referred to as adrenergic.
The final distinction worth making relates to acetylcholine receptors. Remember how all preganglionic neurons use acetylcholine as their neurotransmitter? Well, this means there are acetylcholine receptors in all of the ganglia (specifically, in the postsynaptic cell membrane at the ganglionic synapse, meaning the receptors are proteins that belong to the postganglionic cell). There are two main types of acetylcholine receptors, and it turns out that, just as all preganglionic neurons transmit acetylcholine, all postganglionic neurons tend to have the same type of receptor. This type of ACh receptor can also bind nicotine as a ligand, and is thus referred to as a nicotinic ACh receptor.
Since only the parasympathetic postganglionic neurons use acetylcholine as a neurotransmitter, the second type of receptor can only be found at the synapse between these neurons and their effectors. This ACh receptor can also bind a compound called muscarine as a ligand, and is thus termed a muscarinic ACh receptor.
In summary:
All Autonomic
Preganglionic neuron cell bodies lie in the CNS, and they synapse at ganglia by releasing acetylcholine to nicotinic receptors.
Sympathetic
Ganglia are close to CNS, postganglionic neurons synapse at effectors by releasing epinephrine or norepinephrine onto adrenergic receptors.
Parasympathetic
Ganglia are close to or inside effectors, postganglionic neurons synapse at effectors by releasing acetylcholine onto muscarinic receptors.
*Note: There are exceptions to these guidelines, but they would be given in a passage. For the most part, these hold.
I'll see what I can do. 😉
I owe you guys another one later today actually cause I missed yesterday haha.
Glad I can help! 🙂Beautiful summary 😍 Thanks much
haha your write ups are very good, please dont remove from your study time, i'm trying to be funny and compliment you at the same time. get a good score on this test or i will be upset! 👍
So I'm suppose to know there's 8 Acetyl CoAs in palmitate acid BR??? Ugh...lol
Remember:
Hydroxyl beside methoxy = beta.
Hydroxyl across from methoxy = alpha.
Exactly!
Ganglia, masses of neural cell bodies in the peripheral nervous system, serve as junctions between fibers originating in the CNS and those that synapse with the effectors (either glands or muscles). Preganglionic and postganglionic refer to the location of neurons relative to the synapse at a given ganglion. Since all autonomic nervous signals originate in the CNS, the preganglionic neurons of both the sympathic and parasympathic divisions have their cell bodies located in either the brain or spinal cord. These cell bodies extend axons out to their respective ganglia and synapse with the postganglionic neurons. Since the synapsis actually occurs in the ganglion itself, the postganglionic neurons have their cell bodies within the ganglia, and their axons conduct the signal beyond. These postganglionic neurons are true PNS cells.
Now, what are the differences between the sympathetic and parasympathetic pathways? The two major differences are in location and neurotransmitters used.
Let's address location first: Between the symp. and parasymp. divisions there are differences in the locations within the brain and spinal cord from which the preganglionic signal originates, but let's ignore those for the sake of focus on ganglionic transmission.
Put simply, the sympathetic ganglia are settled close to the CNS and far from the effectors, closest to the spinal cord in the paravertebral region.
In contrast, the parasympathetic ganglia are near to or even inside their effectors.
On to neurotransmitters, as a guideline, the parasympathetic division uses acetylcholine exclusively. Both preganglionic and postganglionic parasympathetic neurons are cholinergic.
As another guideline, all preganglionic neurons use acetylcholine. This means that preganglionic sympathetic neurons use acetylcholine just as the parasympathetic do. However, in the sympathetic nervous system, postganglionic neurons use epinephrine or norepinephrine (adrenaline or noradrenaline) as neurotransmitters instead of acetylcholine. Postganglionic parasympathetic neurons and the receptors they release neurotransmitters onto are referred to as adrenergic.
The final distinction worth making relates to acetylcholine receptors. Remember how all preganglionic neurons use acetylcholine as their neurotransmitter? Well, this means there are acetylcholine receptors in all of the ganglia (specifically, in the postsynaptic cell membrane at the ganglionic synapse, meaning the receptors are proteins that belong to the postganglionic cell). There are two main types of acetylcholine receptors, and it turns out that, just as all preganglionic neurons transmit acetylcholine, all postganglionic neurons tend to have the same type of receptor. This type of ACh receptor can also bind nicotine as a ligand, and is thus referred to as a nicotinic ACh receptor.
Since only the parasympathetic postganglionic neurons use acetylcholine as a neurotransmitter, the second type of receptor can only be found at the synapse between these neurons and their effectors. This ACh receptor can also bind a compound called muscarine as a ligand, and is thus termed a muscarinic ACh receptor.
In summary:
All Autonomic
Preganglionic neuron cell bodies lie in the CNS, and they synapse at ganglia by releasing acetylcholine to nicotinic receptors.
Sympathetic
Ganglia are close to CNS, postganglionic neurons synapse at effectors by releasing epinephrine or norepinephrine onto adrenergic receptors.
Parasympathetic
Ganglia are close to or inside effectors, postganglionic neurons synapse at effectors by releasing acetylcholine onto muscarinic receptors.
*Note: There are exceptions to these guidelines, but they would be given in a passage. For the most part, these hold.
Can anyone please describe to me the difference between a prosthetic group and a cofactor??? Thanks in advance!
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Prosthetic groups are NON-PROTEIN (often are vitamins) molecule that binds covalently to the enzyme's active site. So there is a physical attachment of the prosthetic group to the enzyme.
Whereas...
Co-factors are organic or inorganic substances that are necessary for enzyme function, but they DO NOT react with it.
This isn't what EK says...Prosthetic groups are NON-PROTEIN (often are vitamins) molecule that binds covalently to the enzyme's active site. So there is a physical attachment of the prosthetic group to the enzyme.
Whereas...
Co-factors are organic or inorganic substances that are necessary for enzyme function, but they DO NOT react with it.
EK Biology said:In order to reach their optimal activity, many enzymes requires a non-protein component called a cofactor. Cofactors can be coenzymes or metal ions. Coenzymes are divided into two types: cosubstrates and prosthetic groups. Both types are organic molecules. Cosubstrates reversibly bind to a specific enzyme, and transfer some chemical group to another substrate. The cosubstrate is then reverted to its original form by another enzymatic reaction. This reversion to original form is what distinguishes a cosubstrate from normal substrate [e.g. ATP]. Prosthetic groups, on the other hand, remain covalently bound to the enzyme throughout the reaction, and, like the enzyme, emerge from the reaction unchanged. Coenzymes are often vitamins or vitamin derivatives. [...] Metal ions are the second type of cofactor. Metal ions can act alone or with a prosthetic group.
Thanks. Sparked a nice debate lol but how are you all doing on the physics passages? I did well in physics last semester and feel like i understand it after reading the chapter but when it comes top those passages idk what's going on sometimes...how could i supplement my physics "curriculum"
Anyone else find that they do consistently worse on phase 2? I'm not sure what to make of that.
Edit: I'm doing the br phases, not every third passage like sn2ed suggests.
@GTLO
The information I posted above is directly from TPR Biology Review, page 38. Looking back at it now, this part was not all to clear.
I went and dusted off the Campbell Reece Biology book and it says:
"Many enzymes require nonprotein helpers for catalytic activity. These adjuncts, called cofactors, may be bound tightly to the enzyme as permanent residents, or they may bind loosely and reversibly along with the substrates. The cofactors of some enzymes are inorganic, such as metal atoms zinc, iron, and copper in ionic form. If the cofactor is an organic molecule, it is more specifically called coenzyme. Most vitamins are coenzymes or raw materials from which coenzymes are made."
So cofactor is the broad classification for nonprotein molecules that are needed for an enzyme's catalytic activity. If the cofactor is an organic molecule, it is called coenzyme (vitamins). And I guess from EK bio, coenzymes are further divided into prosthetic group and cosubstrates. I guess the key difference between these two is that prosthetic groups remain attached to the enzyme throughout the reaction and is unchanged.
What the...
Can someone tell me why EK Bio says recapitulation theory is correct?
Page 177, it straight up says "You should be aware that ontogeny reapitulates [sic] phylogeny."
This is most definitely not true (source: http://evolution.berkeley.edu/evosite/evo101/IIIC6aOntogeny.shtml)
Really, EK?
Edit: This can be today's fact!
Ontogeny does not recapitulate phylogeny.
On page 177 of biology, the statement "ontogeny recapitulates phylogeny" is misleading, and is actually the way that Haeckel's refuted recapitulation theory is often stated.
"Haeckel's recapitulation theory claims that the development of advanced species passes through stages represented by adult organisms of more primitive species."
Reference:
Wikipedia contributors. "Recapitulation theory." [i:4351ead9ff]Wikipedia, The Free Encyclopedia[/i:4351ead9ff]. Wikipedia, The Free Encyclopedia, 21 May. 2010. Web. 25 May. 2010.
Instead, the statement should be as follows: "The early embryonic stage of an organism is often similar to the same embryonic stage of related species, but is not necessarily similar to the adult stages of these species. In other words, species which have an evolutionary relationship typically share the early stages of embryonal development and differ in later stages."
So I'm using the 3 month Schedule for the most part and doing some Bio Passages now , Bio EK for content and TBR for passages ........... did anyone do all of those passages listed in The schedule there are at least 11 Passages or did only a few and moved on?
I swear I've been there before but usually there are so few things posted I just ignore it haha...Please be aware of EK's errata forums:
http://examkrackers.com/mcat/Forum/Forum.aspx?f=250
your topic directly:
http://examkrackers.com/mcat/Forum/topics.aspx?f=365&t=19326&tt=Page #177
😛
So tired. I keep trying to catch up but it's not working, I'll have to push the schedule out a few days. That's ok because i've still got a lot of time after I've completed content review.
how's everyone else doing, when do you guys plan to finish content review?
Yeah I cant wait to finish CR assuming I dont gloss over my weakspots. how are your practice tests going? which practice tests are you using?