- Joined
- Jul 7, 2012
- Messages
- 315
- Reaction score
- 3
What again are the basic differences between these two elements of reactions?
Thermodynamic VS Kinematic elements?
- Thread starter Pigglyjuff
- Start date
- Joined
- Mar 25, 2012
- Messages
- 272
- Reaction score
- 84
If I remember correctly, It has to do with the preferance of carbanion stability.
http://www.science.oregonstate.edu/~gablek/CH535/2pentanone.png
Look at that molecule, In thermodynamic pathway, a base would remove the alpha hydrogens on the right carbon because it is more STABLE (secondary carbanion).
In the kinematic pathway, a base would remove alpha hydrogens on the left carbon because it is FASTER and less hindered.
http://www.science.oregonstate.edu/~gablek/CH535/2pentanone.png
Look at that molecule, In thermodynamic pathway, a base would remove the alpha hydrogens on the right carbon because it is more STABLE (secondary carbanion).
In the kinematic pathway, a base would remove alpha hydrogens on the left carbon because it is FASTER and less hindered.
the kinetic products takes less energy to make and thus appears in the products the fastest. this product is less stable than the thermodynamic product, because the thermodynamic product takes more time and more energy to produce a more stable thermodynamic product.
- Joined
- Jul 27, 2009
- Messages
- 803
- Reaction score
- 20
Also, as the kinetic product is formed faster, it usually occurs at the less hindered site (the "easier" route).
- Joined
- Jul 27, 2009
- Messages
- 803
- Reaction score
- 20
Unless you mean what are some things that fall under "kinetic characteristics" and "thermodynamic characteristics" in which case:
Kinetic refers to the rate of reaction. Watch out for things like catalyst (increase rate), temperature (increase rate), activation energy, etc.
Thermodynamics refer to stability. Watch out for things like enthalpy, entropy, equilibrium, etc.
Kinetic refers to the rate of reaction. Watch out for things like catalyst (increase rate), temperature (increase rate), activation energy, etc.
Thermodynamics refer to stability. Watch out for things like enthalpy, entropy, equilibrium, etc.
I think you mean Thermodynamic vs Kinetic?
the best way to explain this would be using enzymes.
Thermodynamic is referring to the Delta G. is the reaction favorable or not. therefore if its a negative delta G, then the reaction is exergonic and it is favourable.
That is what thermodynamics. basically are the products more stable or are the reactants more stable, relatively to each other.
However, a Favourable reaciton might proceed very slowly if it has a very high Ea (activation energy). so this is where the Kinetic elements come. If the reaction has a high kinetic barrier (that is its Ea is too high because maybe its too hard to get the correct collision), then the reaction might proceed very slowly even if its exergonic.
ATP in your body is an example of this. ATP --> ADP is exergonic but it doesn't happen often becuase teh activation energy is way too high.
Thermodynamicly stable reactant = the reaction is endergonic
thermodynamically unstable reactant = the reaction is exergonic
kinetically stable = the reaction is exergonic but high Ea
kinetically unstable = the reaction is exergonic but low Ea.
Learnt it this year in a biochem class 🙂
I was happy when I finally figured it all out.
the best way to explain this would be using enzymes.
Thermodynamic is referring to the Delta G. is the reaction favorable or not. therefore if its a negative delta G, then the reaction is exergonic and it is favourable.
That is what thermodynamics. basically are the products more stable or are the reactants more stable, relatively to each other.
However, a Favourable reaciton might proceed very slowly if it has a very high Ea (activation energy). so this is where the Kinetic elements come. If the reaction has a high kinetic barrier (that is its Ea is too high because maybe its too hard to get the correct collision), then the reaction might proceed very slowly even if its exergonic.
ATP in your body is an example of this. ATP --> ADP is exergonic but it doesn't happen often becuase teh activation energy is way too high.
Thermodynamicly stable reactant = the reaction is endergonic
thermodynamically unstable reactant = the reaction is exergonic
kinetically stable = the reaction is exergonic but high Ea
kinetically unstable = the reaction is exergonic but low Ea.
Learnt it this year in a biochem class 🙂
I was happy when I finally figured it all out.
