Step I thyroid hormone synthesis question

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cosine

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In Goljan Rapid Review page 492, he states that, "thyroid hormone: iodide attached to tyrosine."

I thought that iodide is taken up by the thyroid cell and is converted into iodiNe, then iodine is organified by the tyrosine on the thyroglobulin. So shouldnt it be, "thyroid hormone: iodiNe attached to tyrosine" rather than, "thyroid hormone: iodiDe attached to tyrosine."

Am i missing something here?
 
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1. Iodine becomes Iodide in order to be transported into the thyroid to begin the process.
2. It remains Iodide through the steps of thyroid synthesis, as well as if recycled from MIT or DIT that are not actively secreted.


While you're right in that technically only one Iodine (from the natural I2 state) is attached to the tyrosine residue at the time, charged I (Iodine) is not floating in either the cytoplasm or the follicular lumen...it is created enzymatically at the moment of iodination of the tyrosine.
 
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