Thyroxine and fetal lung development?

[username456789]

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Goljan (audio, and page 281 I believe in the book) say Thyroxine (as well as Cortisol) augments fetal surfactant production.

UW (question ID 550, about surfactant levels) states "neither fetal nor maternal thyroid hormones participate in the lung maturation process."

Thoughts?

 

[mq123]

Goljan (audio, and page 281 I believe in the book) say Thyroxine (as well as Cortisol) augments fetal surfactant production.

UW (question ID 550, about surfactant levels) states "neither fetal nor maternal thyroid hormones participate in the lung maturation process."

Thoughts?

Not a definitive answer, but:

http://forums.studentdoctor.net/showthread.php?t=717835

I would probably go with UW.

 

[ClockworkDoc]

FA talks about cortisone and thyroxine maturing fetal lungs as well

 

[username456789]

I guess this goes along with other debunked dogmas that First Aid still carries, like "Meperedine should be used in patients with biliary disease when an opioid is needed.

 

[mq123]

I guess this goes along with other debunked dogmas that First Aid still carries, like "Meperedine should be used in patients with biliary disease when an opioid is needed.

Had to reply to this -- Goljan also says to use Meperidine for acute cholecystitis pain since morphine (and most other opiods) cause contraction of the Sphincter of Oddi and worsen the pain 🙂 (Goljan RR Path 3rd ed, p. 384)

 

[PokerDoc]

Had to reply to this -- Goljan also says to use Meperidine for acute cholecystitis pain since morphine (and most other opiods) cause contraction of the Sphincter of Oddi and worsen the pain 🙂 (Goljan RR Path 3rd ed, p. 384)

this is actually true

and I was pretty sure corticosteroids increase surfactant production after week 25 in premies, am I to understand from this thread that may not be true?

 

[username456789]

Had to reply to this -- Goljan also says to use Meperidine for acute cholecystitis pain since morphine (and most other opiods) cause contraction of the Sphincter of Oddi and worsen the pain 🙂 (Goljan RR Path 3rd ed, p. 384)

I talked with our head Pharm professor about this, and did a search on my own. This is old thinking, and most current research you'll find pretty clearly states that there's no significant advantage.

 

[InTheMaking]

I talked with our head Pharm professor about this, and did a search on my own. This is old thinking, and most current research you'll find pretty clearly states that there's no significant advantage.

Yup... keep in mind that Goljan audio is from 2002.

 

[username456789]

Yup... keep in mind that Goljan audio is from 2002.

Oops, I should've clarified. This was in reference to the Meperidine thing. Not the surfactant issue.