Step I tissue-plasminogen activator BINDING

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Phloston

Phloston

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We all know that tPA helps convert plasminogen to plasmin during thrombolysis.

Anyway, I got a question in Kaplan QBank about what streptokinase binds to.

I immediately clicked plasminogen as the answer, then paused for a moment.

Now I remember having read somewhere that tPA binds to FIBRIN, not plasminogen, despite the fact that it converts plasminogen to plasmin.

So I thought this was going to be one of those "wtf" questions, where everyone thinks it's plasminogen, but the answer is actually fibrin, and only ~12% get it right.

So I changed my answer to fibrin, and what do you know, 86% got it correct, and the answer was plasminogen! (who's the ****** now? I mean seriously)

Then I flipped to the relevant section in FA, and I had specifically annotated in there, "tPA binds to FIBRIN, not plasminogen."

I'm left thinking, "do streptokinase and tPA bind to different sites? Or had I just annotated from some bogus source?"

Any thoughts?
 
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Phloston said:
We all know that tPA helps convert plasminogen to plasmin during thrombolysis.

Anyway, I got a question in Kaplan QBank about what streptokinase binds to.

I immediately clicked plasminogen as the answer, then paused for a moment.

Now I remember having read somewhere that tPA binds to FIBRIN, not plasminogen, despite the fact that it converts plasminogen to plasmin.

So I thought this was going to be one of those "wtf" questions, where everyone thinks it's plasminogen, but the answer is actually fibrin, and only ~12% get it right.

So I changed my answer to fibrin, and what do you know, 86% got it correct, and the answer was plasminogen! (who's the ****** now? I mean seriously)

Then I flipped to the relevant section in FA, and I had specifically annotated in there, "tPA binds to FIBRIN, not plasminogen."

I'm left thinking, "do streptokinase and tPA bind to different sites? Or had I just annotated from some bogus source?"

Any thoughts?
Click to expand...
streptokinase binds to plasminogen- which exposes an active site in plasminogen and the plasminogen then converts other plasminogen molecules to plasmin.

tpa preferentially activates fibrin bound plasminogen.
so they do bind to different sites.
 
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