TMP/SMX and Type 4 RTA

[MudPhud20XX]

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Can anyone explain why TMP/SMX causes type 4 RTA? It's from FA 2015 page 539.

 

[dfib slim]

Can anyone explain why TMP/SMX causes type 4 RTA? It's from FA 2015 page 539.

Trimethoprim is structurally similar to amiloride, a potassium-sparing diuretic, and can result in hyperkalemia. The rest of the pathophys is explained in that chart.

 

[Transposony]

Trimethoprim inhibits the ENaC channel just like amiloride and triameterene.