TPR ICC Bio Questions

[Jay2910]

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Hey Everyone,

Here is a TPR ICC question from passage 3 of the bio section:

5) Which of the following is most likely to be observed in Rotund mice after several days of starvation?
A) Production of glucose from fatty acids to maintain blood glucose
B) Rapid increase in protein catabolism in muscle, which then decreases over time
C) Increased glycolysis in adipocytes
D) Increased fatty acid biosynthesis in adipocytes


I ruled out C and D . . .but I don't know why A would be the wrong answer. Can any of you enlighten me on this topic? I thought fatty acid breakdown is used to supply glucose into bloodstream. Are these mice an exception?

Thanks in advance!

 

[Bomikepa]

is this q5 or q6 in passage 3?

 

[Temperature101]

Hey Everyone,

Here is a TPR ICC question from passage 3 of the bio section:

5) Which of the following is most likely to be observed in Rotund mice after several days of starvation?
A) Production of glucose from fatty acids to maintain blood glucose
B) Rapid increase in protein catabolism in muscle, which then decreases over time
C) Increased glycolysis in adipocytes
D) Increased fatty acid biosynthesis in adipocytes


I ruled out C and D . . .but I don't know why A would be the wrong answer. Can any of you enlighten me on this topic? I thought fatty acid breakdown is used to supply glucose into bloodstream. Are these mice an exception?

Thanks in advance!

I think production of glucose from fatty acids to maintain blood glucose occurs few hours of starvation...

 

[Jay2910]

Hey,

This is question #6 .. . .sorry about that!

Here's another q that I had trouble on while we are discussing TPR ICC:

This is problem 3 from passage 5:

3) All of the following support the researcher's conclusion that the condition was caused by a Hantavirus EXCEPT:

a) the cDNA probe was complementary to the known Hantavirus m RNA
B) the cDNA probe bound to the .65kb band from infected patients
c) anti Hantavirus antibodies did not bind to lung epithelial tissue samples from healthy patients
D) a serological immune response occurred when infected patients' sera were mixed with known Hantavirus antigens.

Don't they all support the conclusion?

 

[Jay2910]

I think production of glucose from fatty acids to maintain blood glucose occurs few hours of starvation...

But I thought . . .but we have glycogen for that right? cause fat is for long term storage and carbs are for short term.

 

[krogers21]

I believe we use fats and then start breaking down skeletal muscle since it is essentially amino acid storage. And I am unsure about which happens first but I think it goes A, C then B as far as first to last in the event of starvation. I believe D does not relate as starvation doesn't cause synthesis of compounds but catabolism.

 

[HotHamH2O]

Hey Everyone,

Here is a TPR ICC question from passage 3 of the bio section:

5) Which of the following is most likely to be observed in Rotund mice after several days of starvation?
A) Production of glucose from fatty acids to maintain blood glucose
B) Rapid increase in protein catabolism in muscle, which then decreases over time
C) Increased glycolysis in adipocytes
D) Increased fatty acid biosynthesis in adipocytes


I ruled out C and D . . .but I don't know why A would be the wrong answer. Can any of you enlighten me on this topic? I thought fatty acid breakdown is used to supply glucose into bloodstream. Are these mice an exception?

Thanks in advance!

I don't think A is wrong, it's just not as good of an answer as B. In starvation I automatically think of "wasting" in which muscle gets broken down. This is why you see an increase in products of protein metabolism in the urine during fasting ( increase in renal excretion of total nitrogen, urea and creatinine).

 

[inycepoo]

Problem #6 on Passage 3:

During starvation, blood glucose must be maintained for tissues (such as the brain) that require glucose. Glycogen stores are first depleted to provide glucose. Only the glycerol portion of triglycerides, not the fatty acids, can be converted into glucose (A is wrong). Proteins, however, can be converted into glucose. Protein catabolism will initially increase in both Rotund and normal animals. However, over time, tissues adapt to use fats as an energy source, so that protein catabolism is reduced, and muscle is spared (B is correct). During starvation, the adipocyte is largely converting triglycerides into energy that can be released for the rest of the body. Fatty acid oxidation will increase, but glycolysis should not increase (C is incorrect). Also, tissues do not generally perform two reverse pathways at the same time, so during starvation fatty acid oxidation increases, and fatty acid biosynthesis decreases (D is incorrect).

 

[inycepoo]

Problem #3 from Passage 5:

The cDNA probe is expected to be complementary to the known Hantavirus mRNA; after all, it was created from known Hantavirus mRNA. This does not prove that the new condition is caused by a Hantavirus; it proves that the researchers know how to make a cDNA probe. Choice B is true and eliminated; the fact that a probe created from known Hantavirus mRNA bound to mRNA recovered from infected patients says that there must be some similarity between the infected patients' mRNA and Hantavirus mRNA. Choice C is true and eliminated; one would not expect the anti-Hantavirus antibody to bind healthy patients' tissue samples. This is the control that allows the researchers to conclude that binding of the antibody to infected patients' tissue samples reflects the presence of Hantavirus antigens in those samples. Lastly, choice D is true and eliminated; the initiation of an immune response when infected patients' sera are mixed with known Hantavirus antigens says that the infected patients must be making anti-Hantavirus antibodies to another similar version of Hantavirus with which they were infected.

WRT the bolded: lol.

 

[monkeyvokes]

Problem #6 on Passage 3:

During starvation, blood glucose must be maintained for tissues (such as the brain) that require glucose. Glycogen stores are first depleted to provide glucose. Only the glycerol portion of triglycerides, not the fatty acids, can be converted into glucose (A is wrong). Proteins, however, can be converted into glucose. Protein catabolism will initially increase in both Rotund and normal animals. However, over time, tissues adapt to use fats as an energy source, so that protein catabolism is reduced, and muscle is spared (B is correct). During starvation, the adipocyte is largely converting triglycerides into energy that can be released for the rest of the body. Fatty acid oxidation will increase, but glycolysis should not increase (C is incorrect). Also, tissues do not generally perform two reverse pathways at the same time, so during starvation fatty acid oxidation increases, and fatty acid biosynthesis decreases (D is incorrect).

yeah fatty acids are made into acetyl CoAs