transferrin value in hemochromatosis

[MudPhud20XX]

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Guys, it's been a while since my step 1 study, but I got to ask this.
So my understanding is that transferrin elevates in iron deficient state, so why is it elevated in hemochromatosis? Since hemochromatosis is considered as iron overloaded state, shouldn't the transferrin be low?

 

[MudPhud20XX]

Guys, it's been a while since my step 1 study, but I got to ask this.
So my understanding is that transferrin elevates in iron deficient state, so why is it elevated in hemochromatosis? Since hemochromatosis is considered as iron overloaded state, shouldn't the transferrin be low?

Never mind! Lol! I made a fool out of myself. I got confused with TIBC (total iron binding capacity) vs. transferrin lol!
so yeah it makes sense that TIBC will be low. Also, don't forget that transferrin is going to be high although I am not sure if someone who has had hemochromatosis for life, why would transferrin be high since it is considered as an acute phase reactant...

 

[Foot Fetish]

Never mind! Lol! I made a fool out of myself. I got confused with TIBC (total iron binding capacity) vs. transferrin lol!
so yeah it makes sense that TIBC will be low. Also, don't forget that transferrin is going to be high although I am not sure if someone who has had hemochromatosis for life, why would transferrin be high since it is considered as an acute phase reactant...

TIBC is measuring transferrin. For all intents and purposes, you should think of them as the same thing. So, TIBC/transferrin is decreased in hemochromatosis.

 

[MudPhud20XX]

TIBC is measuring transferrin. For all intents and purposes, you should think of them as the same thing. So, TIBC/transferrin is decreased in hemochromatosis.

Transferrin sat goes up in hemochromatosis.

 

[OurDeadGrass]

TIBC is the opposite of transferrin sat. TIBC is measuring empty transferrin, that should go down in hemochromatosis, transferrin sat should go up.

 

[MudPhud20XX]

TIBC is the opposite of transferrin sat. TIBC is measuring empty transferrin, that should go down in hemochromatosis, transferrin sat should go up.

Got it! Thanks for the clarification.