Interesting question. My PS has been all-business, but I spent an hour on the phone yesterday with my supervising physician's mother who happens to be a guru of personal statements (she's in the writing center at MUSC). Straight off the top she wanted me to lead with something significant--in other words, how my best friend's husband's suicide 4 years ago got me to move from Oregon to South Carolina. I would never have thought to use it, but once I did, it flowed. It was a significant event for me in more ways than I could have cognitively identified--so much was undulating below the surface. Once I started writing I remembered all kinds of things; like James (the husband who killed himself in 2004) was one of the first people to get me interested in the PA concept like 14 years ago (I've been a PA for 8 years but was always on the pre-med track). Very stream-of-consciousness.
She also told me a few useful things:
1. Make it personal (duh, "personal" statement)
2. Give a picture of who you are and what you're about
3. Get rid of quotations--nobody reads them anyway
4. "Show me, don't tell me"
5. talk yourself up--things you've done, point out important parts of your application (for me, research as a PA student, teaching experience and a publication)
6. get it down to one page
All ambitious goals, but we'll see. Good luck to you.
Lisa