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Trazadone receptor binding profile
Started by loveoforganic2
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Some say that to be able to hold two contradictory ideas in your head and believe both to be true is a sign of genius. Of course it also the definition of stupidity. Which is a paradox. Thats the thing about paradox....they are paradoxical.
Well, I don't particularly like North Carolina, but I detest Duke. Not all antagonism is the same.
It's best to think of trazodone as a 2A antagonist and 1A partial agonist (like buspirone), as well as an H1/M1 blocker, and consider the other bindings weak enough to be apparently not significant at the doses used. For example, though a 2C blocker, trazodone is not usually associated with metabolic syndrome.
Even better than Ibid's encouragement of doublethink, I would leave you considering a fratboy at a wet t-shirt contest. He throws a bucket of water on the girls, and suddenly the girls are cooled down, but the fratboys find them much hotter. There is some profundity regarding psychopharmacology buried in this, though it may require some sandblasting to uncover.
It's best to think of trazodone as a 2A antagonist and 1A partial agonist (like buspirone), as well as an H1/M1 blocker, and consider the other bindings weak enough to be apparently not significant at the doses used. For example, though a 2C blocker, trazodone is not usually associated with metabolic syndrome.
Even better than Ibid's encouragement of doublethink, I would leave you considering a fratboy at a wet t-shirt contest. He throws a bucket of water on the girls, and suddenly the girls are cooled down, but the fratboys find them much hotter. There is some profundity regarding psychopharmacology buried in this, though it may require some sandblasting to uncover.
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Bring women's breasts into the conversation is a winning strategy but basically its cheating...😡
A quotation
This thread reached the subject of boobs far quicker than I expected (though I did expect it as an eventual inevitability). I guess it's like playing 4 associations to Hitler. Thanks for the help 🙂
Anytime you bring up 5ht1a partial agonism, you're bringing the sexyback.
Stahl published a worthwhile review article on trazodone. I don't have the paper in front of me at the moment, but it should be easily found if you have institution/hospital access to the typical online databases.
*edit*
Stahl SM. Mechanism of action of trazodone: a multifunctional drug. CNS Spectr. 2009 Oct;14(10):536-46.
http://www.cnsspectrums.com/UserDocs/ArticleImages/176/1009CNS_Stahl.pdf
*edit*
Stahl SM. Mechanism of action of trazodone: a multifunctional drug. CNS Spectr. 2009 Oct;14(10):536-46.
http://www.cnsspectrums.com/UserDocs/ArticleImages/176/1009CNS_Stahl.pdf
This is his work to validate the creation and use of oleptro.
Thanks for sharing.
Stahl said:
Seems like the kind of statement that shouldn't be without some kind of citation.
I do like that he mentions trazadone as without sexual dysfunction though
As an aside, during a little google adventure, I did see that mirtazapine was an 5-HT3 antagonist, and actually works great in cancer patients, so that's neat!
Stahl definitely isn't perfect, though I think he does a better job than most when it comes to backing up his statements with research. With that being said, if it was indeed pharma funding (I didn't recall that being the case), then YMMV.
I didn't investigate the article, just perused it with a critical eye after reading nitemagi's comment. I am a good ways off from a DEA#, you don't have to worry about it biasing my prescriptions! Hope I didn't come across as critical of your sharing it
No worries; I did not take any offense.
