So you have a patient who has been a non-responder when given SSRI's, SNRI's, bupropon, and maybe a mood stabalizer. Would you look to ECT, or if you have a wealthy patient, TMS? Or would you consider TCA's or MAOI's? Let's say the patient is not suicidal, with no history of attempts. Let's also assume compliance, and that the dosing of the above were optimized. Also, would your choice differ if the patient has atypical vs. melencholic symptoms?

