Tubulin

[GRAD]

Advertisement - Members don't see this ad

Is Beta Tubulin in the extracellular matrix, and is that an antibody???

 

[bruinpredent]

if i'm not mistaken, Beta Tubulin and Alpha Tubulin make up the mictrotubule filaments found in the cell

http://en.wikipedia.org/wiki/Tubulin


and i guess they can be used as antibodies, who knew:

http://www.abcam.com/index.html?datasheet=15568

 

[Dr. juju]

Is Beta Tubulin in the extracellular matrix, and is that an antibody???

Extracellular Matrix (EM)

Many of the cells in tissues of multicellular organisms are embedded in an extracellular matrix (EM) consisting of secreted proteins and polysaccharides.
The EM fills the spaces between cells and binds cells and tissues together. Basal laminae or basement membranes are an example of EM which support sheets of epithelial cells, and also surround muscle cells, adipose cells, and peripheral nerves.
EM is most abundant in connective tissues. Loose connective tissues beneath epithelial cell layers consists of EM where fibroblasts are distributed. Other types of connective tissue like bone, tendon and cartilage also consist largely of connective tissue which is principally responsible for their structure and function.
EM consists of tough fibrous protein imbedded in gel-like polysaccharides
The major structural protein of EM is collagen, a protein characterized by a triple helical structure.
Connective tissues also contain elastic fibers composed principally of elastin. Elastic fibbers are particularly abundant in organs such as the lung that regularly stretch.
The fibrous structural proteins of EM are embedded in gels formed from polysaccharides, the glycosaminoglycans (GAG). Most GAGs are linked to proteins to form proteoglycans except for hyaluronan.
Adhesion proteins, a third class of EM constituents, are responsible for linking the components of the matrix both to one another and to surfaces of cells. Fibronectin is the principal adhesion protein in connective tissues. Fibronectin has binding sites for collagen, GAG and for cell surface receptors. Basal lamina contains a distinct adhesion protein called laminin.
The major cell surface receptors responsible for the attachments of cells to the EM are the integrins. Integrins are transmembrane proteins of two subunits, alfa and beta. In addition to attaching cells to EM, integrins serve as anchors for the cytoskeleton.
http://www.csupomona.edu/~nebuckley/Courses/Bio310/Lectures/Bio310Lecture13.html

I believe they are a type of tubulin, a protein monomer for making up tubulin in cytoskeleton.

that's all I could get from googling🙂

 

[GRAD]

i seen it on a post once that it was a real ? on the DAT, about what is in the matrix, and i just dont know the answer, but the answers she gave were like antibodies, which i dont think is right, keratin, which i dont think is rigt, and peroxidase and tubulin, and i dunno....

 

[Dr. juju]

i seen it on a post once that it was a real ? on the DAT, about what is in the matrix, and i just dont know the answer, but the answers she gave were like antibodies, which i dont think is right, keratin, which i dont think is rigt, and peroxidase and tubulin, and i dunno....

well, if I remember right, she/he put peroxidase!! well, since she didn't remember the other answer choices, I would stick with peroxidase (that's what she said she put and she got like a 23 on bio) till I see the actual question myself!!!

I know that
peroxidase (POD) and diaminoxidase (DAO) are two extracelluar enzymes.

 

[Djapprentice]

well, if I remember right, she/he put peroxidase!! well, since she didn't remember the other answer choices, I would stick with peroxidase (that's what she said she put and she got like a 23 on bio) till I see the actual question myself!!!

I know that
peroxidase (POD) and diaminoxidase (DAO) are two extracelluar enzymes.

This was a question from Keraro's test: The question was:

What is found in the extracellular matrix?

a) something peroxidase b) tubulin c) keratin d) ? e) ?

I asked my bio teacher this & he said Keratin So I would probably go with that & it does sort of make sense, since kerain is under the epidermis & as keratiocytes are pushed to the top, they accumulate keratin & die out, since keratin is in the exterior, I would probably go with at that.

 

[GRAD]

i looked up stuff for keratin and couldnt find anything...??