So...if I have a patient who took unknown amount of tylenol and the serum concentration is 10 (way below toxic level) and this was measured 5 hours post ingestion, can we figure out how much she took 5 hours ago?
-
CycleTrack and SDN are teaming up to make medical school admissions more transparent and accessible! Read the announcement to learn how we’re supporting the future of CycleTrack’s free application-tracking tools .
Tylenol toxicity...PK question
Started by nagoyankitty
Get help with your application
Use all the free resources available to you from SDN: articles, guides, expert advising, forums discussions, and school research.
Do you understand how half lives work? Look it up - should be pretty easy to determine what her level was immeidately post ingestion - then use bioavailability and Vd to estimate mg ingested
Was it apap er, do od alter normal absorption, bezoar?
This sounds more like you're doing detective work to solve a missing # of tablets, rather than going for overdose treatment stuff. Thanks to how common the latter is, there's a fair amount of PK data for APAP, so you could get a pretty good idea with the way Dred suggested. I'm not convinced it will tell you exactly how many tablets though, because you're going to have some variability using PK parameters.
