I personally do find it a little isolating, but I do get out pretty much as often as possible. I'm about to enter clinics, but this past weekend alone I went to Boston, Worcester, a southern town to hike, and I'm about to go hiking again. Before that I spent some time in Maine. With clinics starting soon, I definitely have more time for that, but I definitely still got out and about while I was in didactics. My grades took a hit, for sure, but for me it was worth it. And honestly, even my more studious classmates get out quite a bit. I do unwind on my own by investing my energy in like, the arts and music and stuff. Having roommates or a good neighbor can help. While in the thick of studying for second-year exams, I'd often go to the public library rather than the school library to feel more like I was part of a broader community.
That all said, it's really not as rural as it appears. I'm like, ten minutes from Target and a boatload of restaurants, bars, gyms, ice rinks, etc. And Worcester is really only a fifteen minute drive. There a lot of signs around that say like, 'thickly settled' and that really is accurate; it doesn't seem like it should be a sprawling area, but there's a good amount of stuff going on.