UW pathology key concepts

[Dr.serotonin]

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Ok guys. I am going through UW pathology. will be posting some of its key concepts in a concise way.
1. PCOS patients are at increased risk of endometrial adenocarcinoma because of unopposed estrogen. the LH:FSH ratio in PCOS is typically greater than 3 with increased production of androgens leading to hirsuitisim.

remember triad of Obesity + hirsuitisim + oligomeorhia

 

[Dr.serotonin]

2. the most susceptible area of brain for hypoxic-ischemic encephalopathy that is global cerebral ischemia are the pyramidal neurons of hippocampus and neocortex and purkinje cells of cerebellum.
5 mins is the max time a neuron structure can withstand ischemia / hypoxia

 

[aspiringmd1015]

th0se arent key UW concepts, straight out of FA.

 

[Dr.serotonin]

th0se arent key UW concepts, straight out of FA.

ofcourse you will find them in FA. but I am posting those which I am encountering while doing UW.

 

[Dr.serotonin]

th0se arent key UW concepts, straight out of FA.

hereditary spherocytosis will be autosomal dominant every where. whether FA or UW. Lol

 

[Dr.serotonin]

3. association of renal papillary necrosis.

a. sickle cell disease / trait.
b. analgesic nephropathy
c. diabetes mellitus
d. acute pyelonephritis & urinary tract obstruction

 

[RLSGrasshopper]

Ok guys. I am going through UW pathology. will be posting some of its key concepts in a concise way.
1. PCOS patients are at increased risk of endometrial adenocarcinoma because of unopposed estrogen. the LH:FSH ratio in PCOS is typically greater than 3 with increased production of androgens leading to hirsuitisim.

remember triad of Obesity + hirsuitisim + oligomeorhia

There was actually a NBME question similar to this, however, it didn't mention PCOS. Rather, any increase (exogenous or endogenous) of estrogen that results in ENDOMETRIAL HYPERPLASIA (or just in general) will increase the risk of Endometrial Adenocarcinoma.

 

[Dr.serotonin]

a women have CIN. which of the following factors might push her into Frank cervical cancer?
A. using OCP
B. having multiple sexual partners
C. smoking
D. radiation exposure
E. immunodeficiency state