Step I Vaccination Q...

[BlackNDecker]

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We were taught that the MMR vaccine is postponed until 12 months b/c maternal Abs might prevent a "take" of the vaccine. If so, then why are other vaccines given as early as 2 months of age(i.e. DPT)?

If anything, it seems administering a conjugated toxin would bind and clear potentially protective maternal Ab's. Or is the purpose to promote APC endocytosis of the Ag-(maternal)Ig complex and subsequent presentation to CD4 cells?

 

[BlackNDecker]

Or is the purpose to promote APC endocytosis of the Ag-(maternal)Ig complex and subsequent presentation to CD4 cells?

This can't be right. Otherwise the CD4 cells could theoretically stimulate B cells to produce IgG, as well as IgA (via isotype switching)...which isn't produced w/ conjugate vaccines.

😕

 

[BlackNDecker]

This can't be right. Otherwise the CD4 cells could theoretically stimulate B cells to produce IgG, as well as IgA (via isotype switching)...which isn't produced w/ conjugate vaccines.

😕

I'm starting to feel like I'm talking to myself now 😳 I guess nobody's responding b/c I didn't mention the words: Goljan, Rapid Review, & BRS Path 😀

I think the answer relates to T cell Independet Ags...
"TI" antigens don't require Tcell help(obviously) because they generate a sufficient signal by either binding outside of the B cell receptor (a la LPS --> TLR4) or by thouroughly cross-linking 2 or more B cell receptors (similar to IgE cross-linking on the surface of mast cells --> degranulation).

I believe in this case the DPT antigens are cross-linking 2 or more mIgM or mIgD. A "normal" infant has produced adequate numbers of mature B cells by birth, and thus could elicit an Ab response independent of CD4+ cell activation.

Anyone have any other thoughts...?

 

[LAZYGUY]

I'm starting to feel like I'm talking to myself now 😳 I guess nobody's responding b/c I didn't mention the words: Goljan, Rapid Review, & BRS Path 😀

The reason nobody is answering you is because you always argue with anybody that tries to help. I mean geez, you tried to answer your own question and then argued with yourself that you were wrong. Get your head out of the books! 🙄

 

[BlackNDecker]

The reason nobody is answering you is because you always argue with anybody that tries to help. I mean geez, you tried to answer your own question and then argued with yourself that you were wrong. Get your head out of the books! 🙄

I'll try to be less argumentative in the future... 👍

BTW, does this have anything to do with our NRDS disagreement? 🙄

 

[LAZYGUY]

I'll try to be less argumentative in the future... 👍

BTW, does this have anything to do with our NRDS disagreement? 🙄

lol, maybe....you're a smart guy, you will do great on the step.


good luck