Hello, I have a little confusion on Vascular curve. I m reading Costanzo an it says that venoconstriction causes the shift of the unstressed volume to stress volume hence increasing the MFSP--> increase venous return shifting the vascular curve to the right. Then the increase of total Peripheral resistance (tpr) reduces venous return and shift the vascular curve to the left. And shift the CO curve right (reducing Co) due to the increased afterload. I can understand the CO part... My question is the increase on veno tone is different from increase TPR? Doesnt the increase of TPR increases VR? From my understanding the increase of TPR is increase in arterial tone. Can anyone clear my confusion?!??