Venlafaxine in GAD

[blackbox89]

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hey guys! I have a quick question because of the mechanism of action of Venlafaxine. It is a SNRI, thats clear. And thus it increases the amount of NE (and Serotonin). But in GAD the NE is already to high,so that doesn`t make sense to me?! Is there any reasonable explanation for it?

 

[Transposony]

hey guys! I have a quick question because of the mechanism of action of Venlafaxine. It is a SNRI, thats clear. And thus it increases the amount of NE (and Serotonin). But in GAD the NE is already to high,so that doesn`t make sense to me?! Is there any reasonable explanation for it?

I think it's action is dose dependent. At lower doses it mainly affects serotonin but at higher doses it affect NE.

 

[blackbox89]

Ok that sounds good, thx!