Viral Replication

[Purp]

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Can someone break down for me the different mechanisms? Or atleast correct my understanding of these?

i.e. for some reason I had no idea that Hep B viruses went DsDNA -> template RNA -> progency DS DNA

while the rest of the DS DNA viruses went DS DNA -> Template DsDNA -> Progency DsDNA

Does that mean Hep B uses DNA-dependent RNA polymerase??

Whereas lets say retrovirus uses a RNA-dependent DNA polymerase because it goes from RNA to DNA.

Do the rest of the RNA viruses then use an RNA-dependent RNA polymerase?
And what about negative stranded RNA viruses?

I should really know this by now lol but I'm not clear from FA and MMRS. Thank you ahead of time.

 

[Cliff Huxtable]

HepB has a reverse transcriptase although it is NOT a retrovirus.

 

[Purp]

Jeez you're right, and it's right there written in FA too.

 

[Cliff Huxtable]

Jeez you're right, and it's right there written in FA too.

Yup, that's the ONLY reason why I know it, lol.

 

[TMP-SMX]

It's an incompletely double stranded DNA virus. The DNA genome enters the nucleus to be transcribed into viral RNA but unlike retroviruses, it doesn't integrate into the host genome itself (the exception is with hepatocellular carcinoma). Some is translated into proteins after leaving the nucleus and the rest is used to create the new genome using viral RT in the viral particles and of course including a host tRNA in the particle as a primer.

 

[Purp]

Just so I don't waste a new thread on this, just a quick question from NBME paraphrased. please don't read on if you plan on taking NBME 6

78 y/o married man who ingested 15 benzo tabs brought to ER. What's most important for assessing risk for suicide?

a) early morning awakening and decreased appetite
b) family suicide history
c) male
d) marrital stat
e) pts belief that temazepam would kill him.

id go with E yah??

 

[vir0n]

Just so I don't waste a new thread on this, just a quick question from NBME paraphrased. please don't read on if you plan on taking NBME 6

78 y/o married man who ingested 15 benzo tabs brought to ER. What's most important for assessing risk for suicide?

a) early morning awakening and decreased appetite
b) family suicide history
c) male
d) marrital stat
e) pts belief that temazepam would kill him.

id go with E yah??

I feel E would be the best answer.

A - depression symptoms
B - There is a correlation
C - more common in females; more likely to succeed in males.
D - Marriage is a protective factor

 

[TMP-SMX]

I think suicide is flipped in the elderly. I think men attempt suicide more often than women. All males are usually more successful but elderly males are the most likely to succeed but because the elderly are far less likely to attempt suicide in the general population, the males still attempt more than females. Rates of suicide for women actually peaks around 50 and then drops.

I could be wrong though and it is heavily dependent on the country. I haven't seen the actual numbers.

 

[bravotwozero]

E would be the correct answer since that implies that the patient knew what he was doing and had a actual plan - one of the strongest risk factors, no?

 

[TMP-SMX]

E would be the correct answer since that implies that the patient knew what he was doing and had a actual plan - one of the strongest risk factors, no?

Yep. A plan is usually the time to take action even before it happens and if it is attempted it's highly likely to happen again if not remedied.