Virus infected cell

[rippinitez]

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Which of the following would be activated first in response to a body cell that has been invaded by a virus?

A. Cytotoxic T cells
B. Natural killer cells
C. Antibodies
D. Macrophages
E. Neutrophils

I know that both cytotoxic and NK cells are involved in attacking virus infected cells, but which comes first?

 

[sfoksn]

I am not sure, but maybe antibodies?
It seems like it woudl be the first one to detect the viral infection...

NK cells are not as in high concentration as antibodies..

T cells aren't in that high concentration either, ad they go through cell-mediated step.

By the time that the cell-mediated response is activated, my thinking is that antibodies already started binding to the antigen...

But then again I have no idea.

 

[prsndwg]

Which of the following would be activated first in response to a body cell that has been invaded by a virus?

A. Cytotoxic T cells
B. Natural killer cells
C. Antibodies
D. Macrophages
E. Neutrophils

I know that both cytotoxic and NK cells are involved in attacking virus infected cells, but which comes first?

I thinks its E

 

[rippinitez]

I don't think it's E because neutrophils are primarily involved in the first line of defense and inflammatory response.

 

[wooki]

antibodies will be one of the responses to viral infection when the infected cells display viral particles on their MHC I.

i dunno whether Ab would be the "first" per se, but that's my answer for this question.

 

[299678]

I think it is natural killer sell for the primary response as non specific

 

[prsndwg]

Which of the following would be activated first in response to a body cell that has been invaded by a virus?

A. Cytotoxic T cells
B. Natural killer cells
C. Antibodies
D. Macrophages
E. Neutrophils

I know that both cytotoxic and NK cells are involved in attacking virus infected cells, but which comes first?

whats the difference between a and b?

 

[Moabmad]

Which of the following would be activated first in response to a body cell that has been invaded by a virus?

A. Cytotoxic T cells
B. Natural killer cells
C. Antibodies
D. Macrophages
E. Neutrophils

I know that both cytotoxic and NK cells are involved in attacking virus infected cells, but which comes first?

The answer should be B. NK cells induce apoptosis for virally infected cells. Their activation occurs through cellular release of interferons by infected cells. They can also be activated by a Macrophage that ingested virus particles outside of the cells.

Cytotoxic T cells are effector T cells that have been activated by encountering their specific antigen epitope on an MHC receptor. This takes time and would not be the first cell activated.

Antibodies is not the correct answer. They do not interact with MHC receptors. Besides a B cell would have to encounter its antigen epitope and differentiate into a Antibody Producing Cell before antibodies would be present to affect any viral particles.

Macrophages and Neutrophils are first line responders but they are professional phagocytes. Typically ingesting debris or bacterial pathogens. The will secrete cytokines which in turn will recruit and activate an NK cell. They do not ingest live cells that are infected with a virus. They will ingest a cell that has ungone apoptosis.

Just my 2 cents. Hope it helps.

 

[rippinitez]

Moabmad, I agree with you completely. In fact I just gave a talk on NK cells in my pathology class. The only thing that is throwing me off is Cliff's. The book says the answer should be cytotoxic T cells.

 

[Moabmad]

Moabmad, I agree with you completely. In fact I just gave a talk on NK cells in my pathology class. The only thing that is throwing me off is Cliff's. The book says the answer should be cytotoxic T cells.

I would argue its wrong. When would a specific response be quicker than a nonspecific.... never. In order for a T cell to become activated some macrophage/dendritic cell would have to phagocytize a viral particle, differentiate into a APC cell, migrate to a lymph node and interact with T's.... seems like cells that are virally infected and secreting interferons would attrack and activate an NK cell alot faster.

 

[rippinitez]

I'm with you. If I see this question on the DAT, I'm going with the NK cell. Thanks again my dude.