Step I Vitamin E and Warfarin

[Northerncardinal]

Acc to FA, Vitamin E can enhance anticoagulant effects of warfarin. what's the mechanism behind this?

thanks/

 

[Phloston]

Apparently it can act counter to vitamin K at hypervitaminotic levels (and yes I probably just created a word).

I'm sure UpToDate probably has a good explanation.

 

[MelMcT2009]

I believe Goljan says Vit E has the same (or similar) mechanism as Warfarin

Acc to FA, Vitamin E can enhance anticoagulant effects of warfarin. what's the mechanism behind this?

thanks/

 

[futuredoctorv]

Vitamin E decreases clotting factors, especially in Vitamin K-deficient individuals, therefore compounding anticoagulant effects of warfarin. Exact mechanism is unknown.

http://www.ncbi.nlm.nih.gov/pubmed/6959563