4424 said:
I seem to get these 2 confused often in UW questions. Can anyone separate them better? Thanks in advance
To echo Bevo's sentiments
Wegner's:
Necrotizing granulomatous vasculitis of medium and small arteries;
4 C's: C-Anca, C-shaped nose deformity, Cough, Crescents (because of increased progression to Rapid Progressive Glomerulonephritis)
Sinusitis, recurrent nasal congestion, hemoptysis, hemorrhagic pulmonary issues (look for this in the history to help distinguish from Goodpasture's);
Imaging: nodular densities may be seen. (as well as infiltrates)
Treatment: Steroids (ie. prednisonse)
Goodpastures:
Type 2 Hypersensitivity
Ab against BM proteins (of glomerular BM and alveolar BM) (Anti-GBM)
Pulmonary hemorrhage, renal failure (oliguria, inc Bun/Cr, etc), hemoptysis
Imaging: pulmonary infiltrates
Treatment: Any time you have Ab you don't want around--> plasmapheresis; also pulsed steroids used.
Hope this helps..
ucb