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Wegener's and Goodpasture's

Discussion in 'Step II' started by 4424, Jul 19, 2006.

  1. 4424

    4424 Senior Member
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    I seem to get these 2 confused often in UW questions. Can anyone separate them better? Thanks in advance
     
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  3. Bevo

    Bevo Radiology, R1
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    I believe wegner's involves the upper rest tract, recurrent sinpulmonary infections.

    Goodpasteur's just involves the lungs and kidneys. this one has ant-GBM antibodies.

    Clinically, the both look the same.

    I forgot which one has which ANCA though. I think Weg's is P-ANCA.
     
  4. ucbdancn00

    ucbdancn00 Senior Member
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    To echo Bevo's sentiments

    Wegner's:
    Necrotizing granulomatous vasculitis of medium and small arteries;
    4 C's: C-Anca, C-shaped nose deformity, Cough, Crescents (because of increased progression to Rapid Progressive Glomerulonephritis)

    Sinusitis, recurrent nasal congestion, hemoptysis, hemorrhagic pulmonary issues (look for this in the history to help distinguish from Goodpasture's);

    Imaging: nodular densities may be seen. (as well as infiltrates)

    Treatment: Steroids (ie. prednisonse)

    Goodpastures:
    Type 2 Hypersensitivity
    Ab against BM proteins (of glomerular BM and alveolar BM) (Anti-GBM)

    Pulmonary hemorrhage, renal failure (oliguria, inc Bun/Cr, etc), hemoptysis

    Imaging: pulmonary infiltrates

    Treatment: Any time you have Ab you don't want around--> plasmapheresis; also pulsed steroids used.

    Hope this helps..

    ucb
     
  5. Leukocyte

    Leukocyte Senior Member
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    C-anca for Wegs. :)
     
  6. Bevo

    Bevo Radiology, R1
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    yeah ....

    I read the more thorough explanation from ubcd above.

    I guess from a question stand point though, the question write would have to include either a positive C-ANCA or a history of the sinopulmonary infections to point towards Wegner's over good pasteures.
     
  7. DNASplicer

    DNASplicer Junior Member
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    good question. I just answered that for myself a few days ago.

    Adding my 2 cents:

    Wegeners is c-ANCA b/c txt w/Cyclophosphamide & Cortiocosteriods
     
  8. 4424

    4424 Senior Member
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    thanks everyone!! :thumbup:
     

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