4424

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I seem to get these 2 confused often in UW questions. Can anyone separate them better? Thanks in advance
 

Bevo

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I believe wegner's involves the upper rest tract, recurrent sinpulmonary infections.

Goodpasteur's just involves the lungs and kidneys. this one has ant-GBM antibodies.

Clinically, the both look the same.

I forgot which one has which ANCA though. I think Weg's is P-ANCA.
 

ucbdancn00

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4424 said:
I seem to get these 2 confused often in UW questions. Can anyone separate them better? Thanks in advance
To echo Bevo's sentiments

Wegner's:
Necrotizing granulomatous vasculitis of medium and small arteries;
4 C's: C-Anca, C-shaped nose deformity, Cough, Crescents (because of increased progression to Rapid Progressive Glomerulonephritis)

Sinusitis, recurrent nasal congestion, hemoptysis, hemorrhagic pulmonary issues (look for this in the history to help distinguish from Goodpasture's);

Imaging: nodular densities may be seen. (as well as infiltrates)

Treatment: Steroids (ie. prednisonse)

Goodpastures:
Type 2 Hypersensitivity
Ab against BM proteins (of glomerular BM and alveolar BM) (Anti-GBM)

Pulmonary hemorrhage, renal failure (oliguria, inc Bun/Cr, etc), hemoptysis

Imaging: pulmonary infiltrates

Treatment: Any time you have Ab you don't want around--> plasmapheresis; also pulsed steroids used.

Hope this helps..

ucb
 
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Bevo

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yeah ....

I read the more thorough explanation from ubcd above.

I guess from a question stand point though, the question write would have to include either a positive C-ANCA or a history of the sinopulmonary infections to point towards Wegner's over good pasteures.
 

DNASplicer

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good question. I just answered that for myself a few days ago.

Adding my 2 cents:

Wegeners is c-ANCA b/c txt w/Cyclophosphamide & Cortiocosteriods
 
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4424

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DNASplicer said:
good question. I just answered that for myself a few days ago.

Adding my 2 cents:

Wegeners is c-ANCA b/c txt w/Cyclophosphamide & Cortiocosteriods
thanks everyone!! :thumbup:
 
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