What class of drug is sirolimus?

[ChessMaster3000]

---

Members do not see this ad.

If you had to name the class of drug sirolimus is in, what would it be? mTOR ligand? (doesn't sound right)

 

[derminterview]

calcineurin inhibitor

 

[DermViser]

If you had to name the class of drug sirolimus is in, what would it be? mTOR ligand? (doesn't sound right)

Immunosuppressants.

 

[NontradCA]

AIDS killer.

 

[seminoma]

If you had to name the class of drug sirolimus is in, what would it be? mTOR ligand? (doesn't sound right)

Immune modulator.

 

[jdh71]

calcineurin inhibitor

nope

rapamycin blocks mTOR, and thereby blocking the upstream signal to produce IL2

 

[jdh71]

If you had to name the class of drug sirolimus is in, what would it be? mTOR ligand? (doesn't sound right)

I'd call it an immune suppressant

 

[ChessMaster3000]

I'd call it an immune suppressant

I appreciate everyone's input, but immunosuppressant isn't specific enough. There are multiple classes of drugs within the larger class of immunosuppressants: steroids, calcineurin inhibitors (which sirolimus is NOT), antimetabolites, biologics, and whatever group sirolimus is in)

 

[Instatewaiter]

I appreciate everyone's input, but immunosuppressant isn't specific enough. There are multiple classes of drugs within the larger class of immunosuppressants: steroids, calcineurin inhibitors (which sirolimus is NOT), antimetabolites, biologics, and whatever group sirolimus is in)

I'm pretty sure it's only real use is to coat stents. I'd go with stent-coater. Is that one of the answer choices?

 

[theSmurfette]

Katzung refers to sirolimus and other mTOR inhibitors (everolimus and temsirolimus) as "mTOR inhibitors". They are also macrolide antibiotics.

 

[CherryRedDracul]

I appreciate everyone's input, but immunosuppressant isn't specific enough. There are multiple classes of drugs within the larger class of immunosuppressants: steroids, calcineurin inhibitors (which sirolimus is NOT), antimetabolites, biologics, and whatever group sirolimus is in)

Then I'd go with macrolide. Tacrolimus is also a macrolide, but it's a calcineurin inhibitor.

 

[seminoma]

I appreciate everyone's input, but immunosuppressant isn't specific enough. There are multiple classes of drugs within the larger class of immunosuppressants: steroids, calcineurin inhibitors (which sirolimus is NOT), antimetabolites, biologics, and whatever group sirolimus is in)

Why does it matter what class you put it in? It inhibits mTOR and is used for immunosuppressing effects. There are multiple classes of antibiotics, yet people still say penicillin is an antibiotic.

 

[ChessMaster3000]

Why does it matter what class you put it in? It inhibits mTOR and is used for immunosuppressing effects. There are multiple classes of antibiotics, yet people still say penicillin is an antibiotic.

For a manuscript

 

[ChessMaster3000]

Then I'd go with macrolide. Tacrolimus is also a macrolide, but it's a calcineurin inhibitor.

Interesting. I think mTOR inhibitor is the most specific--thanks for the input though, I appreciate it.

 

[seminoma]

For a manuscript

If it's for a manuscript I would just look up other recently published manuscripts and use whatever classification they used. Sirolimus is a pretty well known drug so it's probably better to just stick with the trend especially on something so trivial.

Glad you got it figured out though!

 

[jdh71]

If it's for a manuscript I would just look up other recently published manuscripts and use whatever classification they used. Sirolimus is a pretty well known drug so it's probably better to just stick with the trend especially on something so trivial.

Glad you got it figured out though!

You might be surprised by how obtuse and pedantic reviewers can be. Especially those without a clinical background. It's "well known" to people with a clinicla background, but not always so much so to those without.

 

[Kahreek]

You might be surprised by how obtuse and pedantic reviewers can be. Especially those without a clinical background. It's "well known" to people with a clinicla background, but not always so much so to those without.

especially how these agonist, inhibitors, etc "classes" have been proven to be not accurate at all again and again after new research arises.
I am with dermweiser in this one.

 

[DermViser]

I appreciate everyone's input, but immunosuppressant isn't specific enough. There are multiple classes of drugs within the larger class of immunosuppressants: steroids, calcineurin inhibitors (which sirolimus is NOT), antimetabolites, biologics, and whatever group sirolimus is in)

According to Katzung and Trevor's textbook, Basic and Clinical Pharmacology, they are called proliferation-signal inhibitors (PSIs). Both sirolimus and everolimus fall in this category as they "bind circulating immunophilin FK506 binding protein 12 resulting in an active complex that blocks the molecular target of rapamycin (mTOR). The mTOR is a key component of a complex intracellular signaling pathway involved in cellular processes such as cell growth and proliferation, angiogenesis, and metabolism. Thus blockade of mTOR ultimately can lead to inhibition of interleukin-driven T-cell proliferation. Both everolimus and sirolimus also may inhibit B-cell proliferation and immunoglobin production."

 

[seminoma]

You might be surprised by how obtuse and pedantic reviewers can be. Especially those without a clinical background. It's "well known" to people with a clinicla background, but not always so much so to those without.

Would someone without a clinical background really be one to argue that "immunosuppressant" is too broad for sirolimus, though?

I was just saying that sirolimus is likely in thousands of peer-reviewed papers already and sticking with what the classification used by all those authors might be less problematic than trying to reclassify the drug.

 

[ChessMaster3000]

Would someone without a clinical background really be one to argue that "immunosuppressant" is too broad for sirolimus, though?

I was just saying that sirolimus is likely in thousands of peer-reviewed papers already and sticking with what the classification used by all those authors might be less problematic than trying to reclassify the drug.

Haha, didn't expect to generate this level of discussion. Without getting into the details of the manuscript, for this paper, classifying sirolimus as "immunosuppressant" would indeed be way too broad. I really appreciate everyone's input. mTOR inhibitor it is.