i completely agree with lance.
if a good portion of your essay actually is dedicated to all the compelling reasons you want to go there, and you're able to make real school specific individual claims, regarding things like location, curriculum, campus, environment, research, facilities, rotation sites, some kind of club they have, somehow it would prolly seem more real than all of us who are writing secondaries based on the websites and brochures. that adcom will know you want to go there more.
but if you are going to put numbers on your secondaries, don't go with #2 and definitely not #22.