What exactly does 'eosinophilic infiltrate' mean?

[Daitong]

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For example, as with Loffler syndrome (endomyocardil fibrosis with a prominent eosinophilic infiltrate', I'm unsure that that actually means.

Similarly, when something is described as basophilic, I understand how it's stained, but what does that imply?

Thanks in advance,

 

[watchmenaenae]

Eosinophilic infiltrate means that a lot of eosinophils ( white blood cells) are present within the tissue.
Eosinophilic staining = it's pink in color.
Basophilic staining = it's blue in color.


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[Daitong]

Eosinophilic infiltrate means that a lot of eosinophils ( white blood cells) are present within the tissue.
Eosinophilic staining = it's pink in color.
Basophilic staining = it's blue in color.


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Thanks! So eosinophilic = white bloods cells, but what typically does basophilic staining imply, then?

 

[watchmenaenae]

Eosinophilic staining is not the same as eosinophilic infiltrate.
These are two different things.
When we talk about eosinophilic infiltrate that means eosinophilic cells are infiltrating inside of the tissue and they are now abundant in that tissue.

When we say the tissue is eosinophilic that means it appears histologically pink in color after staining (even without eosinophilic cells). I hope it's clear



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[Tajima]

It's confusing because the term eosinophilic can mean both "pink staining" and "exhibits numerous eosinophils". Also confusing is that the term basophilic ONLY means "blue staining". I've never seen it used to refer to a tissue staining with numerous basophils.

As a general rule, if they say "eosinophilic INFILTRATE" it means the tissue has a lot of eosinophils in it.

 

[Entadus]

Eosinophilic infiltrate has lots of eosinophils. Eosinophils exhibit eosinophilic staining due to the protein content of their cytotoxic granules. They are stained well by eosin.

 

[Daitong]

Ok thankss!!!

 

[worldbeater]

Also in context, Loffler's syndrome is dealing with parasites like Ascaris Lumbricoides, so it would make sense that there be an increase in eosinophils to come attack the invading worms.