Step I What is the mechanism of decrease glucose uptake by Growth Hormone?

[sylhet]

1. we all know that growth hormone decreases glucose uptake in adipose tissue and skeletal muscle while on the contrary insulin increases glucose uptake in adipose tissue and skeletal muscle. I know how insulin increases glucose uptake (by increasing the number of GLUT-4 transporters). But how growth hormone decreases glucose uptake? a different or similar mechanism?😕

2. How exactly high levels of free fatty acid decrease the uptake of glucose in skeletal muscle and adipose tissue? 😕

 

[DoctwoB]

1. we all know that growth hormone decreases glucose uptake in adipose tissue and skeletal muscle while on the contrary insulin increases glucose uptake in adipose tissue and skeletal muscle. I know how insulin increases glucose uptake (by increasing the number of GLUT-4 transporters). But how growth hormone decreases glucose uptake? a different or similar mechanism?😕

2. Growth hormone increases blood glucose level and in response insulin goes up but insulin can't work. They said high fatty acid(growth hormone increases fatty acid level and i know how) level resist the action of insulin. How exactly insulin cant work in presence of high fatty acid level?😕

What I heard is that growth hormone induces IGF1, which essentially antagonizes insulin at its receptor.