I feel kind of dumb having to ask this question, but I'm having difficulty deciding if this article is considered "primary literature" or "secondary." We have to do a presentation from an article from the primary literature. It can't be a case report, case series, review article, a meta-analysis, or an editorial. I was confused about this one here because it says they are using data from 1984 although this paper was just published in 2009. I included the title and abstract below.
Br J Haematol. 2009 Jul;146(2):180-4. Epub 2009 May 19.
Possible lower rate of chronic ITP after IVIG for acute childhood ITP an analysis from registry I of the Intercontinental Cooperative ITP Study Group (ICIS).
Tamminga R, Berchtold W, Bruin M, Buchanan GR, Kühne T.
Paediatric Haematology-Oncology, Beatrix Children's Hospital, University Medical Centre Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands. [email protected]
Abstract
In children, one-third of immune thrombocytopenic purpura (ITP) patients follow a chronic course. The present study investigated whether treatment with intravenous immunoglobulin (IVIG) at the time of diagnosis of ITP is of prognostic significance, using data from 1984 children entered in Registry I of the Intercontinental Cooperative ITP Study Group. A matched pairs analysis compared children with thrombocytopenia (platelet count <150 x 10(9)/l) 6 months following diagnosis with children whose platelet count was normal 6 months after diagnosis. It was found that children initially treated with IVIG were more likely to have a normal platelet count 6 months after diagnosis than children not receiving IVIG (odds ratio 1.81; 95% confidence interval: 1.25-2.64). This result was independent of age, gender, country of origin, platelet count at diagnosis or infection preceding the diagnosis of ITP. In a similar analysis, comparing children with a platelet count <50 x 10(9)/l 6 months after diagnosis with children whose platelet count was > or =50 x 10(9)/l at that time point, the former group was less often treated with IVIG than with steroids (P = 0.02). Prospective studies are required to further explore this potential effect of IVIG.
Br J Haematol. 2009 Jul;146(2):180-4. Epub 2009 May 19.
Possible lower rate of chronic ITP after IVIG for acute childhood ITP an analysis from registry I of the Intercontinental Cooperative ITP Study Group (ICIS).
Tamminga R, Berchtold W, Bruin M, Buchanan GR, Kühne T.
Paediatric Haematology-Oncology, Beatrix Children's Hospital, University Medical Centre Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands. [email protected]
Abstract
In children, one-third of immune thrombocytopenic purpura (ITP) patients follow a chronic course. The present study investigated whether treatment with intravenous immunoglobulin (IVIG) at the time of diagnosis of ITP is of prognostic significance, using data from 1984 children entered in Registry I of the Intercontinental Cooperative ITP Study Group. A matched pairs analysis compared children with thrombocytopenia (platelet count <150 x 10(9)/l) 6 months following diagnosis with children whose platelet count was normal 6 months after diagnosis. It was found that children initially treated with IVIG were more likely to have a normal platelet count 6 months after diagnosis than children not receiving IVIG (odds ratio 1.81; 95% confidence interval: 1.25-2.64). This result was independent of age, gender, country of origin, platelet count at diagnosis or infection preceding the diagnosis of ITP. In a similar analysis, comparing children with a platelet count <50 x 10(9)/l 6 months after diagnosis with children whose platelet count was > or =50 x 10(9)/l at that time point, the former group was less often treated with IVIG than with steroids (P = 0.02). Prospective studies are required to further explore this potential effect of IVIG.
