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- Mar 26, 2015
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36 year old guy presents to our hospital for the first time. Has delusions of being a billionaire, having record labels, owning buildings etc. The guy's homeless. Also had a thrombosis and required Warfarin and will need INR checks at least for several months.
Came to the hospital dehydrated, confused (likely due to the dehydration) and with the thrombosis that was treated. We do not know why he was dehydrated. He doesn't remember. I speculate it was the winter months that were very cold and he couldn't find a source of water.
Tried on 3 antipsychotics at high dosages, no benefit. He has no signs or sx of psychosis other than the delusions. ADLs are fine. You can't tell he even has psychosis unless you bring up the delusions. He doesn't want to take meds but they were court-ordered.
So it's possible he has Delusional Disorder, a disorder that doesn't respond well if at all to meds.
Pimozide was tried with no real benefit. It was tried because there is some data with it and delusional disorder. Guy's been in the hospital 40 days. Way too long IMHO and part of it is because the way the inpatient schedule has been, inpatient attendings have rotated on it and left it for the next guy.
So here's the problem. Guy still is psychotic but there's not direct danger from his delusions. Fine. But he cannot pay for his Warfarin treatment and refuses govt assistance because he insists he is a billionaire. Already tried the rational arguments (if you were really a billionaire the gov would either deny you the stuff you don't qualify for, or you would get the stuff anyone even with money could get).
Should this guy be discharged --> and then not be able to afford his Warfarin treatment? He understands and has capacity that needs that treatment.
Or kept in the hospital-possibly indefinitely given that delusional disorder possibly could not be treated with meds?
If kept in, would you up the ante and try Clozapine or ECT given that there's hardly any data showing they work for delusional disorder? What would you do?
And everything you pretty much think of such as labs to see if it was something that could be isolated, collateral (there is none) have turned up nothing of substance.
Keep and treat? Or discharge?
Why would they put him on neuroleptics? Neuroleptics make people slow, anxious, and depressed which is why they do not treat delusional disorder. They are used to make people docile, indifferent, and compliant. All they do is block dopamine and seratonin - they don't rewire the brain.
He seems highly invested in his delusions. That is why he is holding onto them so tight. Deep down, he knows he is not a billionaire with record labels. He is using the delusions to cope with other things that neuroleptics will probably make worse.
I never understood why psych wards always go straight to neuroleptics for everyone. Those drugs are very powerful and hurt people very bad. Most the people coming into a psych ward are already under enough mental distress without neuroleptics. I would argue that most people in psych wards are not mentally ill but instead mentally distressed with no actual illness. And when they are ill, neuroleptics are still not a good treatment.
The dopamine hypothesis has never had proof with regards to psychosis. Let alone just delusions. Giving the guy akithisia, anxiety, and extreme depression is not going to help him.
If all your ward will do is torment him with neuroleptics and put him in group, you might as well discharge him. Even if he stops claiming what he claims to get out, he will go right back to using those delusions to cope when he leaves.