It really depends. The school I will be matriculating at this summer definitely took a "holistic" approach when looking at my app and ultimately inviting me for interview and accepting me. Both GPAs were under 3.4 and the school's posted average is 3.6. My MCAT was very pedestrian as well. This tells me that they looked mostly at my post-bacc GPA (3.8) rather than my undergrad GPA (3.2). I was also complimented on my extensive research and clinical volunteering.
The takeaway message here is, you never know. If you were to ask people for a list of schools that do "holistic review", you'd honestly be SOL. There are just too many variables and every admissions office is staffed by people who are looking for different things. Obviously, it is easier just to assume that higher numbers are what they look for, because that's what the statistics show time and time again. My best advice is to highlight your strengths and definitely address your weaknesses if appropriate and when asked. You may get that one ADCOM member at X school of medicine who will indeed look at your application more holistically.
EDIT: Also, I want to add. Have a great non-trad friend who also went through a post-bacc program. Both GPAs under 3.0. Post-bacc GPA a near 4.0. Invited to 2 MD interviews, acceptances pending. N=1, I don't think you'd be "throwing away" your money at all by applying to MD schools.
