Not all programs operate the same way. Some programs will offer only Monday and Friday options. Some will offer some weekend options. Some will offer random dates through November, December, and January with no apparent pattern to the dates offered. Some will have a set pattern for which they interview (every Tuesday). Some will start interviewing in early November, some will not start interviewing under December. Some will offer you dozens of options, other will offer you three options. Some will have a dinner the night before, some will not. Some will pay for a hotel room, others will not.
While it is possible to schedule all your interviews in one region, it can be challenging. The way it works is you will receive emails through the ERAS software, or occasionally emails directly from the programs inviting you for an interview. These emails usually contain the available dates to interview. These emails will trickle in during Sept through October (sometimes even into November if you were "waitlisted"). Therefore it is difficult because you may schedule one interview in NYC with "Program A" on November 18, and then get an interview invitation several weeks later from "Program B", also in NYC, but they only interview once a week, and that happens to be also on November 18th as well, or they don't start interviewing until December, or their November dates are already full because you did not reply to their email ASAP. Then you're faced with the difficult task of deciding do you a) call back Program A and ask to reschedule to accomidate Program B and your traveling plans or b) Make 2 trips to NYC or c) Not interview at Program B or d) as to be waitlisted for an interview spot at Program B in November, etc.
You need to be very flexible during interview season. That is why I recommend taking December or January off of clinical duties if possible. Realize also that interviewing is a tiring process. It's constant shaking hands, being asked "what questions do you have for me", listening to presentations about programs. Also many programs will have you interview with anywhere from 2-6 people. You need to always be "on your game", scheduling too many interviews close together may get to be too tiring.