when to start maintenance dose after loading dose

[jarjar5606]

When should maintenance dose be started after a loading dose. If loading dose for nexium is 80mg, then maintenance drip at 8mg/hr, that's 80mg every 10 hours. Do i start the drip 10 hours after the loading dose or can i start the drip right after the loading dose?
thanks for the help

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[njac]

Start the maintenance drip as soon as you finish the bolus.

 

[smileyangel11]

In most cases, if it is a continuous IV infusion drug, the main. dose starts right after bolus.

 

[type b pharmD]

is this question mildly amusing to anyone else?

 

[WVUPharm2007]

is this question mildly amusing to anyone else?

Yes.

 

[eightball]

Yes.

Thought provoking question (BTW this is a valid question)

Why on earth are PPI continuous drips done?? PPIs are irreversible inhibitors and thus just need to strike once, and are good for at least 24 hours. what does a drip accomplish?

 

[type b pharmD]

Yes.

So if i give a loading dose, and then initiate maintenance therapy two days later, that loading dose still counts right??

 

[WVUPharm2007]

Thought provoking question (BTW this is a valid question)

Why on earth are PPI continuous drips done?? PPIs are irreversible inhibitors and thus just need to strike once, and are good for at least 24 hours. what does a drip accomplish?

Guidelines say otherwise in GI bleed, playa. And until they amend the guideline...you follow the guidelines. Though you might be right. Later and smaller studies have shown little difference in continuous vs intermittent dosing. But if you deviate from guidelines, lawyers come a-knockin'...

 

[WVUPharm2007]

So if i give a loading dose, and then initiate maintenance therapy two days later, that loading dose still counts right??

If its Vanc, the patient is 105 years old, and has a CrCl of 7....yes....

 

[type b pharmD]

If its Vanc, the patient is 105 years old, and has a CrCl of 7....yes....

haha

 

[npage148]

I always start the maint dose 5 half-lives after the bolus