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Step I why aortic regurgitation increases PP?
Started by BornDJnowDoc
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Pulse pressure = SBP-DBP
In AR some blood is regurgitated back into the left ventricle during diastole this leads to an increase in end diastolic volume in the left ventricle which --------> Frank starling mechanism-------> increase force of contraction--------> increase ejection fraction or stroke volume.
In AR some blood is regurgitated back into the left ventricle during diastole this leads to an increase in end diastolic volume in the left ventricle which --------> Frank starling mechanism-------> increase force of contraction--------> increase ejection fraction or stroke volume.
^finishing his point increasing stroke volume will increase systolic bp, moreover since blood is regurgitating back there will be less blood going to the circulation resulting in a decreased diastolic as well so increase systolic and decrease diastolic widens the pp, anyone feel free to correct me tho
B
Beezlebub
"Less blood going to the circulation" - Frank Starling Law compensates for that by increasing contractile forces when SV/EDV are increased as in cases of AR, or other circumstances involving volume overload. It makes sense intuitively, b/c if less blood is going to the systemic circulation, it would place the body at risk for decreased blood perfusion -> dec O2 diffusion -> tissue necrosis -> organ failure -> death.
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