Why do uncoupling agents on the ETC result in hyperthermia?

[whatdidigetinto]

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Can anyone please explain it to me? I understood the physiological aspect but i dont understand why the temperature increases.

 

[Myxedema]

Oxidative phosphorylation is ultimately a chemical reaction, where the energy created by the electrochemical gradient across the mitochondrial membrane is converted to form the high energy bonds in ATP. Uncouplers create an alternate pathway for protons, so the electrochemical gradient and the energy is still there, but it isn't used to form ATP. Instead, that conserved energy just dissipates as heat (think about an exothermic reaction).

 

[whatdidigetinto]

Thanks for the answer!
Also, i just listened to Goljan say this:
''Uncouplers cause H+ to go right through the membrane, we get very little ATP, and since our body is in total equilibrium, if you start draining protons off,, then the reactions that were generating the protons to begin with (i.e. the reactions that make NADH and FADH) will increase. And you all know that when the rate of a chemical reaction increases, what happens? The temperature increases.''