Why does furosemide cause calcium loss?

[anbuitachi]

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So furosemide causes calcium loss, but I don't really understand it since calcium is reabsorbed paracellularly in TAL.

Furosemide blocks NKCC, so the charge balance is the same... so why is calcium not absorbed as much?

Also why does thiazide decrease calcium excretion..?
Thanks

 

[Ycut]

So furosemide causes calcium loss, but I don't really understand it since calcium is reabsorbed paracellularly in TAL.

Furosemide blocks NKCC, so the charge balance is the same... so why is calcium not absorbed as much?

Also why does thiazide decrease calcium excretion..?
Thanks

normally after NaKClCl absorption K back diffuses into lumen and causes net increase in positive charge in lumen which repels Ca and Mg forcing their absorption

thiazides block NaCl absorption that decreases intracellular Na activating Na/Ca exchanger on basal membrane depleting intracellular Ca that favors more Ca absorption in the presence of PTH

 

[anbuitachi]

normally after NaKClCl absorption K back diffuses into lumen and causes net increase in positive charge in lumen which repels Ca and Mg forcing their absorption

thiazides block NaCl absorption that decreases intracellular Na activating Na/Ca exchanger on basal membrane depleting intracellular Ca that favors more Ca absorption in the presence of PTH

Thanks!!! super helpful