Why is kidney affected the most in systemic amyloidosis?

[studylol]

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Proteins are excluded from passing into the glomerulus due to their bulkiness. Shouldn't amyloids behave similarly?

Thanks!

 

[SBR249]

Think about what happens after the filtration by the glomeruli step, since most of the plasma has been filtered by the glomerulus, what's left (the protein and cellular fraction) are much more concentrated which means it's now much easier for amyloid to aggregate, precipitate and deposit in the peritubular tissue leading to greater damage.

 

[nidusiamnot]

Hah I read it as WHICH kidney. Overthinking does take a toll.

 

[studylol]

Think about what happens after the filtration by the glomeruli step, since most of the plasma has been filtered by the glomerulus, what's left (the protein and cellular fraction) are much more concentrated which means it's now much easier for amyloid to aggregate, precipitate and deposit in the peritubular tissue leading to greater damage.

Of course! I didn't think the damage can happen at the arterial level. Thanks a lot.

 

[Robotman]

Hah I read it as WHICH kidney. Overthinking does take a toll.

Wow I thought read the same thing.