Why is phosphate normal/high in Myeloma (compared to e.g. hyperPTH)?

[Maxilla54]

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Why is phosphate normal/high in Myeloma?

(Compared to e.g. in hyperparathyroidism where phosphate levels are opposite to that of Calcium i.e. decreased in primary/tertiary and increased in secondary).

 

[7331poas]

I mean, in hyper para thyroidism you have high PTH causing phosphate excretion. In MM you do not.

 

[Internist_Sandman]

MM causes bone destruction (lytic lesions), to which i have always ascribed hypercalcemia.

 

[QuizzicalApe]

MM causes bone destruction (lytic lesions), to which i have always ascribed hypercalcemia.

Correct, in MM there is a ramping up of osteoclasts without getting the osteoblasts sufficiently jazzed for their own job potentially resulting in lytic lesions and/or hypercalcemia

 

[Maxilla54]

I mean, in hyper para thyroidism you have high PTH causing phosphate excretion. In MM you do not.

Damn of course.
What a stupid question. I must've been feeling weird when I wrote this. My other qs are usually more interesting ahaha