Why would there be low renin hypertesion in 17 hydroxylase and 11 hyrdoxylase de

[cooldude89]

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Why would there be low renin hypertension in 17 hydroxylase and 11 hyrdoxylase deficiency, shouldn't renin increase because it is causing the hypertension? right?

 

[loveoforganic2]

IIRC, 17 hydroxylase deficiency causes shunt to aldosterone, and 11 hydroxylase deficiency causes shunt to a semi-functional aldosterone precursor. So you have primary aldosterone or "aldosterone" mediated hypertension and thus low renin

 

[viper930]

IIRC, 17 hydroxylase deficiency causes shunt to aldosterone, and 11 hydroxylase deficiency causes shunt to a semi-functional aldosterone precursor. So you have primary aldosterone or "aldosterone" mediated hypertension and thus low renin

This. 17hydroxylase deficiency completely shunts things to the mineralocorticoid pathway so that's easy to understand. 11 hydroxylase deficiency leaves you with 11-deoxycorticosterone (product of 21-alpha hydroxylase) which has partial mineralocorticoid effect. This is also how you can distinguish 21-alpha hydroxylase deficiency from 11-alpha hydroxylase deficiency (normo/hypotension vs hypertension, respectively)