If you are asking why you would work for a chain vs. starting an independent then it is a matter of risk. While the job quality and revenue potential are much greater with an independent, there is also greater risk in the form of potential lawsuits (since you are liable for costs due to malpractice- although of course you can and probably should buy insurance [another cost]) as well as the business not performing. With Rite Aid or a similar company, you are pretty much guaranteed your pay even if the store doesn't make much (unless the store closes and you are laid off, but that is a lower chance). At the end of the day it depends on what type of person you are and how risk averse you are. Some people would rather not take the additional liabilities and risk on or might not be so into the business aspects of running an independent. Others, might think it is a great opportunity and try it out.