Wild Speculation

[shepardsun]

Sad ending to a hopeful story. Can't think of many rare fatal genetic reactions to anesthesia specifically besides MH. Having never seen it myself, I fear I have developed a simulation-induced misconception that you just need to recognize it and push the dantrolene and everything will be fine. Clearly not always the case.

 

[26B]

Seems like MH is the most likely scenario.

Could also be MTHFR mutation if N2O was used?
Influence of Methylenetetrahydrofolate Reductase Gene Polymorphisms on Homocysteine Concentrations after Nitrous Oxide Anesthesia | Anesthesiology | ASA Publications

"Recently, two reports describing children carrying several polymorphisms and mutations in the MTHFR gene were published. The children developed catastrophic neurologic outcomes after being anesthetized with nitrous oxide."